🌿 Kindness - Spreading Goodness And Kindness To The World
  • Kindness
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  • Believe in Good
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  • Book of Kindness
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Our Purpose on Earth
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • The Brain on Cannabis
  • Marijuana Use
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  • The Miracle of Coffee
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  • Plastic Bottles
  • Brain Health
  • The Danger of Wireless
  • Cellular Phones
  • Salt in Our Diet
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  • Do Not Use Oil at All
  • Most Destructive Food
  • Most Harmful in Food
  • Fat & Sugar Do Not Mix
  • Oils and Brain Function
  • The Real Problem
  • Stop Heating Oil
  • Cooking Without Oil
  • Olive Oil is Bad for You
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  • Juicers / Blenders
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  • Benefits of Oranges
  • Grapefruit
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  • Blood Brain Barrier
  • Polluted Brain
  • MERCURY
  • Heal Your Brain
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  • High Vibrational Foods
  • Green for Life
  • Food and Frequency
  • Soy the Deadly Poison
  • The Common Cold
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  • Phytoplankton
  • IODINE is the Key
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  • Organic Banana
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • MENTAL ILLNESS
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Mental Health
  • End of Mental Illness
  • Heal Your Brain
  • Hope for Mental Illness
  • ADD & ADHD
  • List of SSRI Medication
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  • BPA and Phthalates
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  • APEEL
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  • Eat Your Vaccine
  • Food Poisoning - 2O23
  • The Fountain of Youth
  • Renewable Water
  • Iridology
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  • Miracle of Breathing
  • Stop Mouth Breathing
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  • Libertà
  • Who Will CRY?
  • Acts of Kindness
  • Light for the World
  • Simple Act of Kindness
  • ​Message to the People
  • Village Life
  • Swearing
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Protect Your Kidneys
  • Protect Your Teeth
  • Protect Your Eyesight
  • Save Your Tonsils
  • Fatty Liver
  • Sodium & Potassium
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  • Food for Aging
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  • Hot Water Cure
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  • Why People are Sick
  • Why are They Spraying
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  • Healing for the Sick
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  • Heal Eye Problems
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  • Mucusless Diet
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  • Not Stored in Fridge
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  • Natural Remedies
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  • Books You Need in Life
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  • AGNI the General
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  • Cancer
  • Acidic Body
  • Cancer Heals
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  • Dr. Null and Dr. Lodi
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  • Toxic Laundry
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  • Drinking With Meals
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  • 🌿 L O S E W E I G H T
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  • How to Lose Weight
  • Lose Weight / 2
  • Pure and Simple / 1
  • Pure and Simple / 2
  • Detox Pinial Gland
  • Green for Health
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Food Combining
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  • Fat and Sugar
  • 80 - 10 - 10 Diet
  • Danger of Sugar & Fat
  • P. Ovary Syndrome
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  • 🌿 R E T R E A T S
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  • World Health Retreats
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Avoid Natural Flavors
  • GMO Food
  • Glyphosate
  • H2o / Sodium Fluoride
  • Poison of the Century
  • Silent Killer / MSG
  • Sugar / Bitter Truth
  • Sore Throat - Use Zink
  • Vitamin D
  • 5 LOX - Lethal Enzyme
  • What are Prions?
  • Worst Ingredient ...
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  • Funny French Videos
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  • What is GcMAF?
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  • Extremely Dangerous
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  • World's 6 Best Doctors
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  • Autoimmune Disease
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  • Miracle of Cucumber
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  • DHA Deficiency
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  • Danger of Vinegar
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  • Extremely ​Toxic
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  • What are Lectins?
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  • How to Make Kefir
  • Coconut Kefir
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Global Intoxication
  • Suicide Cult
  • Snitch Culture
  • The Hidden Truth
  • War Against Marriage
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  • The Invisible Rainbow
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • ANTHONY WILLIAM
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Medical Medium
  • Medical Medium Book
  • Miracles of Parsley
  • Healing Foods
  • Heavy Metal Detox
  • Parkinson's Disease
  • The Story
  • International Books
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  • Educational Page
  • Healing Foods
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • 🌿 J U I C I N G
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  • Celery Juice
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  • The Miracle of Juicing
  • Juicers / Blenders
  • Juicing - Jay Cordich
  • Deception / Raw Juice
  • Naked Juice
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Linus Paulig
  • Vitamin C
  • Cancer & Vitamin C
  • Dr. Hoffer's Vitamins
  • 6000 x Vitamin C
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  • Astaxanthin
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  • Truth About Cancer
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  • Danger of PLASTIC
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  • Unsafe at Any Meal
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  • Hybrid Foods
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  • Health Videos
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  • MMS
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  • Coffee /Alcohol / Brain
  • Coffee / Deadly Poison
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  • Coca Cola and Soda
  • McVegan Burger
  • Avoid Alzheimer
  • Alzheimer's and Prion
  • Worse Than Cigarettes
  • Everyone is Allergic
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  • Uplifting Music
  • The Best of Kuranesh
  • The Habit
  • Friend of the Animals
  • Just a Mother
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  • Bio Superfood
  • Power of Q 96
  • What the Health
  • Bragg Aminos / Poison
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  • Super Nutrition
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  • Cure for Headache
  • Diet for Acne
  • High Doses / Vitamin D
  • Research on Aging
  • Repair Your DNA
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  • The Story of My Life
  • The Tombstone
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  • Grandfather's Wisdom
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  • 🌿 D I A B E T E S
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  • Reverse Diabetes
  • Nutrition for Diabetes
  • What to Eat / Diabetes
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  • 🌿 B E A U T I E S
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  • Beauty of Character
  • Beauty of Children
  • Beauty of Kindness
  • Beauty of Women
  • The Beauty of Man
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  • Beauty of Animals
  • Beauty of Clouds
  • Beauty of Birds
  • Beauty of Desert
  • Beauty of Macro
  • Beauty of Winter
  • Beauty of Flowers
  • Unique Flowers
  • Poems
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  • 🌿 K I N D N E S S
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  • Kindness & Gratitude
  • Kindness & Swearing
  • Kindness & Generosity
  • Kindness / Individuality
  • Kindness & Happiness
  • Kindness and Freedom
  • Kindness & Love
  • Kindness in SPAIN
  • Kindness Quotations
  • Fairy Magic Songs
  • Just Play a Song
  • No Negative People
  • Paradox of Our Age
  • A Film for Peace
  • A Revolutionary Idea
  • Behind ​Pornography
  • Book of Kindness
  • Letter of Love
  • Money and People
  • Poverty
  • Prayer for My Children
  • Videos on Kindness
  • Radiation of Kindness
  • Why Walk We Can Fly
  • Who Will Dare to Love
  • The Origins of Music
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  • Message of Peace
  • 365 Days for Travelers
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  • Homeless
  • Need or Greed
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  • Courageous Woman
  • Food of Kindness
  • Kindness Only
  • Universal Quotes Facts
  • Signs of the Times
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  • Divorce and Children
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  • 🌿 H A P P I N E S S
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  • Ho'oponopono
  • Key to Happiness
  • Happiness and Peace
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  • Happy Place on Earth
  • Happy Place on Earth 2
  • Trap of Materialism
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  • 🌿 H E A L T H
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  • 🌿 M O V I E S
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  • Our Daily Poison
  • Earthling
  • Food Inc. / Cowspiracy
  • Food Matters
  • Forks Over Knife
  • Health Videos
  • Thrive / Full Movie
  • Origins Movie
  • Powerful Speech
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  • Film About Life
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  • 🌿 C A N C E R
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  • Cure Cancer
  • Cure with Wheatgrass
  • Cancer... / Dr. Circus
  • Cancer Risk / At Home
  • Cancer & Vitamin C
  • Dr. Leonard Caldwel
  • Ginger & Cancer
  • Hot Dog = Cancer
  • Potato Chips
  • Thyme / Chamomile
  • 7 Top Cancer Foods
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  • Truth About Cancer
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  • 🌿 G R A S S / C U R E
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  • Miracle of Wheatgrass
  • 50 Reasons
  • Super Food Living
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  • 🌿 M A G I C A L
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  • 🌿 M A R K U S
  • R O T H K R A N Z
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  • Magical Recipe
  • Incredible P I Z Z A
  • Loose Weight / Markus
  • Heal Your Face
  • Heal Yourself 101
  • Edible Weeds
  • Raw Food Ideas
  • Miracles
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  • 🌿 H O W - T O
  • L O S E - W E I G H T
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  • How to Lose Weight
  • Loose Weight / Markus
  • Raw Food / Works
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  • World Peace Diet
  • The 80 - 10 - 10 Diet
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  • 🌿 W O R S T F O O D
  • 🌿 W H E A T / E T C .
  • G L U T E N F R E E
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  • Wheat Belly
  • Bread
  • Gluten Brain
  • Extreme Dangers
  • Food for Faster Aging
  • Is Wheat Poison?
  • Is Quinoa Gluten Free?
  • Is Corn Gluten-Free?
  • No Starch for Infants
  • Rice / High in Arsenic
  • Worst Food # 1
  • Dark Side of Wheat
  • Mental Health / Gluten
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  • 🌿 R A W - F O O D
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  • Raw Food
  • Fully Raw Videos
  • Garden Diet
  • Raw Food Recipes
  • Goldenseal
  • Most Pesticides Food
  • Real Raw Food Canada
  • Tanny Raw
  • 30 x Nutrition
  • 10 Healthiest Fruits
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  • Avoid Acidity
  • Best Papaya
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  • 🌿 G R E E N - T H E
  • M I R A C L E - F O O D
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  • Green Smoothies
  • Green Smoothies / 2
  • Red Malabar Spinach
  • Is Kale a Miracle Food?
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  • Moringa / Super Food
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  • 🌿 R E T R E A T S
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  • World - Listings
  • ECUADOR Paradise
  • Garden of Healing
  • Eden Home Resort
  • Raw Retreat Costa Rica
  • Rancho La Puerta
  • Dr. Sebi's Healing
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  • 🌿 C O F F E E
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  • Dr. Amen on Coffee
  • Dangers of Coffee
  • Side Effects of Coffee
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  • 🌿 C A C A O
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  • Dangers of Cacao
  • Cacao / 2
  • Carob
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  • 🌿 S U N L I G H T
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  • Sunlight the Miracle
  • Sungazing
  • Sunlight by Dr. Kime
  • Solar Civilization
  • Sunlight / Sungazing
  • Sabiduria Cosmica
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  • 🌿 M E A T
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  • Meat
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  • Five Poison in Meat
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  • Avoid Some Fish
  • Chicken
  • Food Inc.
  • A Powerful Speech
  • Hot Dog = Cancer
  • Meat of the Future
  • Beyond Vegetarianism
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  • 🌿 F A S T F O O D
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  • Extremely ​Toxic
  • Fast Food
  • Children & Junk Food
  • Fast Food Poison
  • French Fries
  • Is Subway Real Food?
  • McDonald”s Food USA
  • Mockery of Humanity
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  • 🌿 G M O
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  • What is GMO Food?
  • Glyphosate
  • Glyphosate News
  • GMO News
  • GMO and the DNA
  • 20 GMO Food
  • GMO Products
  • 1000 X Toxic
  • Please Wake Up!
  • Against Humanity
  • GMO Bans and Laws
  • GMO Corn
  • GMO & Russia
  • GMO Linked to Gluten
  • Health Ranger
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  • 🌿 A L U M I N U M
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  • Dark Side of Aluminum
  • Aluminum / Autism
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  • 🌿 C O O K W A R E
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  • Aluminum Cookware
  • Cookwares Danger
  • Crock Pots
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  • 🌿 G E O
  • E N G I N E E R I N G
  • C H E M T R A I L
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  • Reasons Behind
  • Geo Engineering / 1
  • Geo Engineering / 2
  • Geo Engineering / 3
  • Complete Theory
  • Climate Control
  • Chemtrail Material
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  • What Chemtrails Are
  • Vaccines / Chemtrails
  • Chemtrail Protection
  • Engineered Drought
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  • 🌿 S O L U T I O N
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  • Solution for Chemtrail
  • Population Control
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  • 🌿 M O R G E L L O N S
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  • Morgellons Disease
  • Morgellons / 2
  • Old Age
  • Harald Kautz - Vella
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  • 🌿 R A D I A T I O N
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  • 5G Cell Phone Dangers
  • Radiation
  • Radiation / West Coast
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  • 🌿 O R G A N I C
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  • Go Organic
  • Eating Organic
  • Culinary Nightmares
  • Eating Healthy / Mental
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  • 🌿 A V O C A D O
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  • Miracle of Avocado
  • Avocado / 2
  • Avocado SEED
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  • 🌿 C O C O N U T
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  • Miracle of Coconut
  • For Dental Health / 1
  • For Dental Health / 2
  • Why Palm Sugar?
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  • 🌿 M I R A C L E
  • F O O D
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  • Green Smoothies
  • Miracle of Greens
  • Miracle of Wheatgrass
  • Miracle of Wild Green
  • Is Kale a Miracle Food?
  • Miracle of Alfalfa
  • Miracle Root / Beet
  • Miracle of Cherry
  • Miracle of Fulvic Acid
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  • How to Make Kefir
  • Miracle Goat Milk
  • Miracle of Lemon
  • Walnut
  • 5 "Careful" Super Food
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  • 🌿 B A N A N A
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  • Miracle of Banana
  • Banana / Loose Weight
  • Banana / Miracle Fruit
  • Banana and Mango
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  • 🌿 A L O E - V E R A
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  • Aloe Vera
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  • 🌿 T O B A C C O
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  • Organic Tobacco
  • Cigarette Additives
  • Eating vs. Smoking
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  • 🌿 F R E E B O O K S
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  • Dr. Shelton / Free PDF
  • Books on Health
  • Tissue Cleaning
  • Diet by Design
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  • Anastasia
  • I Ching Book
  • Napoleon Hill
  • The Power of Now
  • The Power of Now / 2
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  • 🌿 H E A L T H
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  • Calm Nerves
  • Diet in Few Words
  • DOLLAR Stores ?
  • Canola Oil / Facts
  • Food for the Eye
  • Mitochondria
  • Natural Cures
  • Organic Sulfur
  • Sunlight
  • The Silent Ecocide
  • 92 Side Effects
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  • I M M U N I Z A T I O N
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  • Immunization
  • History of Medication
  • Untold Horrors
  • Vaccines / Chemtrails
  • Vaccination Via Air
  • Vaxxed
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  • 🌿 S. F L U O R I D E
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  • H2o / Sodium Fluoride
  • Sodium Fluoride / 2
  • Sodium Fluoride / 3
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  • 🌿 W A T E R
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  • Plastic Bottles & BPA
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  • Alkaline Water
  • Test for Fluoride
  • H2o Alkalinity
  • H2o Ionizers
  • How to Mineralize H2o
  • Fluoride Toxicity
  • H2O / Empty Stomach
  • What Water to Drink
  • Water & Lemon Juice
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  • 🌿 C O C A - C O L A
  • S O D A S
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  • Coca Cola and Soda
  • Red Bull etc.
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  • 🌿 S U G A R
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  • Sugar / Bitter Truth
  • Aspartame
  • Aspartame Poisoning
  • Cancer Risk to Millions
  • Erythritol / Sugar
  • Honey
  • Maple Sugar
  • Molasses
  • Why Palm Sugar?
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  • 🌿 D E T O X
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  • Liver & Kidney Cleanse
  • Tissue Cleaning
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  • Replace Prednison
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  • 🌿 H E A L I N G
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  • Alzheimer, Arthritis / 1
  • Arthritis / 2
  • Food for Inflammation
  • Ear Infection
  • Heartburn
  • Prions & Alzheimer
  • Shingles
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  • 🌿 D E N T I S T R Y
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  • Dental Health / 1
  • Dental Health / 2
  • Magnesium for Teeth
  • Root Canal
  • Toxic Teeth
  • What is Wrong
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  • 🌿 D A N G E R S
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  • Dangers of Cocoa
  • Danger of Grapes / 1
  • Dangers of Microwave
  • Dangers of Night Shade
  • Dangers of Salt
  • Potato
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  • Grapefruit/Medication
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  • Onion Toxicity
  • Toxic Garlic
  • 10 Top Poisonous Food
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  • 🌿 M I L K
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  • Truth about Milk
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  • 🌿 T O X I C F O O D
  • A D D I T I V E
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  • Our Daily Poison
  • Toxic Food Additives
  • Toxic Pizza
  • Pesticide in Citrus
  • Poison on Your Platter
  • Toxic Light Bulbs
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  • 🌿 W E L L N E S S
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  • Iridology
  • Maggot Therapy
  • Stool Examination
  • Over 1000
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  • 🌿 C O S M E T I C S
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  • Dangers of Make-Up / 1
  • Dangers of Make-Up / 2
  • Natural Cosmetics
  • Toxic Cosmetics
  • Heal Your Face
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  • 🌿 C H I L D R E N
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  • Dr. Mendelson
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  • 🌿 MENTAL - HEALTH
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  • Niacin / Mental Illness
  • Niacin / Vitamin B3
  • Niacin Deficency
  • Real Story of Niacin
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  • Schizophrenia
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  • Lithium Orotate
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  • Dr. D. G. Amen Clinic
  • Anxiety
  • Anxiety / 2
  • Can Autism Be Cured
  • Gut and Mental Illness
  • Heal Depression
  • Help for Mental Illness
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  • Dr. Abram Hoffer
  • Dr. Hoffer's Vitamins
  • Dr. Andrew Saul Videos
  • Shocking Effects
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  • Mental Health / Gluten
  • Mental Health & Wheat
  • Medication Withdrawal
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  • 🌿 V I T A M I N S
  • M I N E R A L S
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  • Vitamin D
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  • Ascorbic Acid / Avoid It
  • Calcium Supplement
  • Vitamin C
  • Vitamin K2
  • Niacin / Vitamin B3
  • Niacin Deficency
  • Niacin / Mental Illness
  • Selenium
  • Real Story of Niacin
  • B 12
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  • Magnesium / 1
  • Magnesium / 2
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  • 🌿 E X E R C I S E
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  • Benefits of Trampoline
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  • 🌿 G A R D E N I N G
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  • Starvation is Over
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  • Back to Eden
  • Better than Organic
  • Organic Gardening
  • Secret of Eldorado
  • $300 Greenhouse
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  • 🌿 G E N E R A L
  • I N F O R M A T I O N
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  • Paul Harvey / 1965
  • Art
  • Charlotte Iserbyt
  • Educational / Hand
  • Free Energy
  • Food Contains Nanite
  • Fibonacci Numbers
  • How to Tip
  • Home Sweet Home
  • How to Grow Rich
  • Hunza People
  • Ice Cube Effect
  • Kellogg
  • Kundalini Rising
  • Long Hair
  • More Than Reality
  • Sad Story
  • The Universe
  • Valhalla Culture
  • World Toughest Job
  • 8 Toxic People
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  • Artificial Intelligence
  • Artificial Intelligence II
  • Black Goo
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  • No More Prednison
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  • 🌿 F L O W E R S
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  • Flowers Unimaginable
  • Rózsa Özön
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  • 🌿 M U S I C
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  • Panflute Collection
  • Around the World
  • Beauty of Music
  • Carlo Gallozzi - Music
  • Child / Anak
  • Encouragement
  • Kitaro - Music
  • Libertà - Italian
  • Lona - Music
  • Michele Ippolito
  • Music
  • Music for Anxiety
  • Miel de Booton / Music
  • Music 2 / Beethoven
  • Secret Garden - Music
  • MUSIC
  • Andreea Petcu - Music
  • Michel Pépé
  • Steve McDonald
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  • 🌿 H I S T O R Y
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  • Ancient Mystery
  • Chinese Wisdom
  • Dragonology
  • The Future
  • The Great Controversy
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  • 🌿 I N T E R V I E W S
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  • Simon Parkes
  • Harald Kautz - Vella
  • Harald Kautz - Vella / 2
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  • 🌿 ENTERTAINMENT
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  • Entertaining Videos
  • Humorous
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  • Treasures of Info.
  • The Snake
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  • Consciousness
  • Freedom of Speech
  • Law of Attraction
  • Simple Truth Movies
  • 45 Wisdom for Man
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  • Mucusless Diet
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  • 🌿 P R O B I O T I C
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  • Coconut Yoghurt
  • Cultured Food Life
  • Probiotic / BB 536
  • How to / Kombutcha
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  • 🌿 K E F I R
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  • History of Kefir
  • The Value of Kefir
  • How to Make Kefir - 2
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  • Sun Light Lamp
  • Sleeping
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  • Clean Your Arteries
  • Clean the Mercury
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  • Calcium Removal
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  • 🌿 A N T I - A G I N G
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  • Secret of Long Life
  • Anti Aging Diet
  • Elder Action
  • Inflammation of Aging
  • Telomere / Anti Aging
  • Young Again
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  • Monoatomic Gold
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  • Senior Discount
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  • 🌿 MISCELLANEOUS
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  • Age of Treason
  • Articles / Whole Food
  • Chia Seed
  • Contaminated
  • Doctor Yourself . Com
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  • Epson Salt
  • FODMAP Food List
  • For Beautiful Hair
  • Heal Gout Naturally
  • Health Science
  • Iodine
  • Iron Absorption
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  • Miracle Treasure Book
  • Pictures With Meanings
  • Points of Diseases
  • Rice / Tomato / Potato
  • Rife Machine
  • Today's Worst Disease
  • Future Vaccination
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  • 🌿 M I X E D / I N F O
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  • Food Craving
  • Friends
  • Hydrogen Peroxid
  • Improve Your Vision
  • Improve Your Vision /2
  • Books
  • How to Make Oetmeal
  • STEVIA DANGER
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  • 🌿 MIRACLE of NIACIN
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Mental Health Re-Evaluated
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File Type: pdf
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“ For schizophrenics, the natural recovery rate is 50%. 

With orthomolecular medicine, the recovery rate is 90%. 

With drugs, it is 0%. 

If you use just drugs, you won’t get well. 

This is because mental illness is usually biochemical illness. 

Mental illness is a disorder of brain dysfunction.

Schizophrenia is vitamin B3 (niacin) dependency.

Not a deficiency, a dependency. 

If schizophrenia strikes someone at age 25, he’s finished. 

That is, if he’s only given drugs.

Patients are given drugs and released. 


The new mental hospital today is the streets.”

Dr. Abram Hoffer
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Use Only Niacin or Inositol Hexaniacinate 

Do not use Niacinamide

The starting dose of niacin for adults is 

1,000 mg 3 times daily...

The daily dose should be slowly increased 

to 4,500-18,000 mg to achieve the best possible outcome for Mental Illness.

Patients must be educated about the flushing, heat, itchiness, pruritis, redness, and tingling that they will transiently experience. 

These benign cutaneous reactions usually begin 15 minutes after taking niacin for the first time, and are first noticed around the forehead, then descend to the thorax, and sometimes to the feet. These reactions typically abate 1-2 hours following the ingestion of niacin. Niacin causes such cutaneous reactions by inducing the production of prostaglandin D2 in the skin, leading to vasodilation and a marked increase of its metabolite (9α, 11β-PGF2) in the plasma.

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Niacin is its own anti-flushing agent because taking it regularly depletes the skin of prostaglandin D2 and prevents subsequent cutaneous reactions. 

At 3,000 mg daily, 

the flush and other symptoms will cease to be an issue following the first 2-3 days of treatment, and will practically disappear thereafter. If patients are not consistently taking these optimal doses throughout the day, they will continually re-experience cutaneous reactions and possibly discontinue treatment. 

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Niaciamide / Not Recommended / Can Cause Liver Toxicity

The concern over liver toxicity is very minor if immediate-release niacin preparations are used.

Timed - release preparations can cause liver toxicity and are not recommended for schizophrenic patients unless under very close supervision. 

In Prousky’s clinical experience, niacin is more effective and better tolerated than niacinamide for schizophrenia. 

Some patients prefer niacinamide since it does not cause flushing or other cutaneous reactions. Nausea and dry mouth are much more common with the use of niacinamide than with niacin. 
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Successful Treatment of Schizophrenia 
​

Requires Optimal Daily Doses of Vitamin B3

Alternative Medicine Review Volume 13, Number 4 2008  

For over 50 years Dr. Abram Hoffer has been educating clinicians about the need to correctly (optimally) dose schizophrenics with vitamin B3 (niacin; niacinamide). For the past 10 years I have, likewise, educated numerous naturopathic and medical doctors about the very same thing. 

For some reason, both types of clinicians routinely treat schizophrenic patients with plenty of vitamins, minerals, and other natural health products, but they never provide enough vitamin B3. In these authors opinions, schizophrenic patients cannot get well if not provided with optimal doses of vitamin B3. This prevents the real acceptance of nutritional treatment since clinicians will not observe favorable results when inadequate treatment is provided; their schizophrenic patients will continue to suffer needlessly.

To understand the importance of vitamin B3 treatment, some background information
is needed. Schizophrenia is characterized by a combination of perceptual changes (e.g., hallucinations) and thought disorders (e.g., delusions).1 These aberrant mental states, which can lead to psychotic behavior, cause a tremendous amount of emotional and psychological suffering. The cause of schizophrenia, the subject of much debate, is considered a biochemical imbalance, although certain genetic factors most certainly play a role.

The majority of scientists and psychiatrists subscribe to the dopamine excess theory of schizophrenia; i.e., that too much dopamine is largely responsible for the symptoms of psychosis. However, since 1952, Hoffer, the founding father of orthomolecular medicine, has researched, published, and expanded on the adrenochrome theory of schizophrenia.1,2 He and his colleagues, Drs. Osmond and Smythies, arrived at this theory by studying and researching the effects of substances such as mescaline, lysergic acid diethylamide (LSD), and amphetamines – all of which can cause a clinical syndrome in normal individuals that would be clinically indistinguishable from schizophrenia.

Osmond and Smythies noted that mescaline had a similar chemical structure to that of adrenaline. Hoffer, Osmond, and Smythies concluded that since both can be converted to indoles in the body, the potential schizophrenic toxin might be an indole derivative of adrenaline with similar neurochemical properties to that of mescaline or LSD. They eventually deduced that the schizophrenic toxin was an oxidized derivative of adrenaline known as adrenochrome. Since the early 1950s, the adrenochrome theory has been validated by the following findings:  

  1. Adrenochrome and its close relatives – dopaminochrome (from dopamine) and noradrenochrome (from noradrenaline) – are present in the human brain.3-5

  2. These compounds probably induce a combination of neurotoxic and mind- mood-altering effects.3-5

  3. Reducing adrenochrome, dopaminochrome, and noradrenochrome is therapeutic for the treatment of schizophrenia.6

To reduce the production of adrenochrome, Hoffer and his team decided on the methyl acceptor vitamin B3. This vitamin, previously used to treat pellagra (a disease clinically indistinguishable from schizophrenia) had relevant biochemical properties.1,2 Hoffer and his team researched the metabolism of adrenaline. They knew that the reaction involving noradrenaline to adrenaline required the addition of one methyl group. 

Because vitamin B3 was known to function as a methyl acceptor, Hoffer’s team theorized that an optimum dose of niacin might decrease the amount of noradrenaline that would be converted to adrenaline. Since adrenochrome was thought to be an oxidized derivative of adrenaline, vitamin B3 could help reduce the quantity of adrenochrome by simply limiting the production of adrenaline.

Hoffer and his team also discovered an additional biochemical property of vitamin B3 that would help to explain its therapeutic efficacy. Vitamin B3 is a precursor to nicotinamide adenine dinucleotide, which is present in both oxidized (NAD) and reduced (NADH) forms in the body. In the brain, adrenaline loses one electron to become oxidized adrenaline. If enough NAD and NADH are available then the oxidized adrenaline is reconverted to adrenaline. 

These back and forth processes continue to occur in the presence of sufficient vitamin B3 coenzymes. However, in the absence of sufficient NAD and NADH, the oxidized adrenaline loses an additional electron and becomes adrenochrome. This last reaction is irreversible, and presumably occurs in much greater concentrations in the schizophrenic brain.

That being said, where is the proof? Can vitamin B3 help in the treatment of acute
and chronic schizophrenia? The first report on the therapeutic use of vitamin B3 for schizophrenia was presented in 1952 at the Saskatchewan Committee on Schizophrenia. At this meeting, eight cases were presented, each demonstrating favorable effects from giving 1-10 g vitamin B3, and, in the majority of cases, equal amounts of vitamin C.1 After a more involved pilot study demonstrated excellent therapeutic responses to vitamin B3,1 the first North American double-blind, placebo-controlled experiment was undertaken to assess whether or not this vitamin was effective for schizophrenia. 

The study, which began in 1952 but was not published until 1957, involved 30 acute schizophrenic patients who were each randomized to placebo, niacinamide, or niacin. They were given 1 g three times daily for 30 days, and then followed for one year. After one year, the patients given vitamin B3 with the standard treatments at that time had more than double the recovery rate (80%) compared to patients in the placebo group (33%).7

Hoffer followed patients from 1953 to 1960, publishing a total of six double-blind, randomized controlled clinical trials. All trials confirmed the positive effects that vitamin B3 had on the recovery of acute schizophrenic patients, and that the use of this vitamin substantially reduced patients’ reliance on the health care system. 2

In a more recent analysis of 27 chronic schizophrenic patients who had been under treatment for at least 10 years, consistent treatment with vitamin B3 produced the following results: 11 patients were able to work; two patients were able to marry and look after their families and homes; two patients were single mothers able to care for their children; and three patients were able to manage their own businesses.9 These results are remarkable when one considers the state of these patients prior to receiving optimal doses of vitamin B3. The average age of these patients was 40, the majority of them were ill for seven years before they sought treatment from Hoffer, and all had been unresponsive to previous treatments.

The starting dose of niacin for adults is 1,000 mg three times daily. In our opinion, the daily dose should be slowly increased to 4,500-18,000 mg to achieve the best possible outcome. Patients must be educated about the flushing, heat, itchiness, pruritis, redness, and tingling that they will transiently experience. 

These benign cutaneous reactions usually begin 15 minutes after taking niacin for the first time, and are first noticed around the forehead, then descend to the thorax, and sometimes to the feet. These reactions typically abate 1-2 hours following the ingestion of niacin. Niacin causes such cutaneous reactions by inducing the production of prostaglandin D2 in the skin, leading to vasodilation and a marked increase of its metabolite (9α, 11β-PGF2) in the plasma.10 

Niacin is its own anti-flushing agent because taking it regularly depletes the skin of prostaglandin D2 and prevents subsequent cutaneous reactions. At 3,000 mg daily, the flush and other symptoms will cease to be an issue following the first 2-3 days of treatment, and will practically disappear thereafter. If patients are not consistently taking these optimal doses throughout the day, they will continually re-experience cutaneous reactions and possibly discontinue treatment.

The concern over liver toxicity is very minor if immediate-release niacin preparations are used.11,12 Timed-release preparations can cause liver toxicity and are not recommended for schizophrenic patients unless under very close supervision.13 In Prousky’s clinical experience, niacin is more effective and better tolerated than niacinamide for schizophrenia. 

Some patients prefer niacinamide since it does not cause flushing or other cutaneous reactions. Nausea and dry mouth are much more common with the use of niacinamide than with niacin. The daily dosages of niacinamide should not exceed 6,000 mg since the likelihood of nausea accompanied with vomiting is much greater.14

As clinicians we need to offer restorative care to patients who suffer with schizophrenia,
a severe and usually chronic mental illness. The only reasonable conclusion to be made from this data is that all schizophrenic patients, including both acute and chronic patients, need to be treated with vitamin B3 as quickly as possible and for the duration of their lives. 


Vitamin B3 treatment offers significant hope of a reasonable quality of life among patients who would otherwise remain incapacitated and in and out of hospitals for the remainder of their lives. Some might improve so much that they achieve clinical remission. Since not enough clinicians utilize optimal doses of vitamin B3 with their schizophrenic patients, we hope that the information presented here persuades other clinicians to adopt this very effective and safe treatment.

Respectfully,

Abram Hoffer, MD (retired), PhD Jonathan Prousky, ND

Abram Hoffer, PhD, MD, FRCP(C), ROHP – President, Orthomolecular Vitamins Information Centre; professor psychiatry, 1955-1967; Director Psychiatric Research, Department Health, Saskatchewan, 1950-1967; President Emeritus, International Schizophrenia Foundation; Editor, Journal Orthomolecular Medicine; 2007 winner of Dr Rogers Prize; pain in the neck to orthodox psychiatry. Correspondence address: 2727 Quadra Street, Suite 3A, Victoria BC, V8T 4E5

Jonathan E. Prousky, BPHE, BSc, MSc, ND – Chief Naturopathic Medical Officer and professor of clinical nutrition, Canadian College of Naturopathic Medicine.

References

  1. Hoffer A. Vitamin B-3 & Schizophrenia. Discovery, Recovery, Controversy. Kingston, ON: Quarry Press, Inc; 1998:28-76.

  2. Hoffer A. Adventures in Psychiatry. The Scientific Memoirs of Dr. Abram Hoffer. Caledon, ON: KOS Publishing Inc; 2005:50-99.

  3. Smythies J. Endogenous neurotoxins relevant to schizophrenia. J R Soc Med 1996;89:679-680.

  4. Smythies JR. Oxidative reactions and schizophrenia: a review-discussion. Schizophr Res 1997;24:357-364.

  5. Smythies J. The adrenochrome hypothesis of schizophrenia revisited. Neurotox Res 2002;4:147-150.

  6. Hoffer A. The adrenochrome hypothesis and psychiatry. J Orthomol Med 1999;14:49-62.

  7. Hoffer A, Osmond H, Callbeck MJ, Kahan I. Treatment of schizophrenia with nicotinic acid and nicotinamide. J

    Clin Exp Psychopathol 1957;18:131-158.

  8. Hoffer A. Niacin Therapy In Psychiatry. Springfield, IL: Charles C. Thomas; 1962;35-71.

  9. Hoffer A. Chronic schizophrenic patients treated ten years or more. J Orthomol Med 1994;9:7-37.

  10. Morrow JD, Parsons WG 3rd, Roberts LJ 2nd. Release of markedly increased quantities of prostaglandin D2 in vivo

    in humans following the administration of nicotinic acid. Prostaglandins 1989;38:263-274.

  11. Hoffer A. Vitamin B-3 and schizophrenia. Townsend Lett Doctors Patients 2001;213:20-23.

  12. Paterson ET. Vitamin B3 and liver toxicity. Townsend Lett Doctors Patients 2001;207:23.

  13. Mullin GE, Greenson JK, Mitchell MC. Fulminant hepatic failure after ingestion of sustained-release nicotinic acid.

    Ann Intern Med 1989;111:253-255.

  14. Hoffer A. Vitamin B-3: niacin and its amide. Townsend Lett Doctors Patients 1995;147:30-39.

  15. Hoffer A. Healing Schizophrenia. Toronto, ON: CCNM Press Inc; 2004:7-21.

  16. Horrobin D. The Madness of Adam and Eve. London, England: Corgi Books; 2001:149-151.

  17. Hoffer A. Treating chronic schizophrenic patients. J Orthomol Med 2002;17:25-41.

  18. Goeree R, Farahati F, Burke N, et al. The economic burden of schizophrenia in Canada in 2004. Curr Med Res Opin 2005;21:2017-2028. 
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