🌿 Kindness - Spreading Goodness And Kindness To The World
  • Kindness
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  • Acts of Kindness
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  • Simple Act of Kindness
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  • Believe in Good
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  • ​Message to the People
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  • Light for the World
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  • 🌿 🌿 🌿 🌿 🌿 🌿 🌿
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  • Lifetime Wisdom
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  • 🌿 🌿 🌿 🌿 🌿 🌿 🌿
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  • The Common Cold
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  • Most Harmful in Food
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  • Fat & Sugar Do Not Mix
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  • The Miracle of Coffee
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  • The Brain on Cannabis
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  • Marijuana Use
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  • 🌿 🌿 🌿 🌿 🌿 🌿 🌿
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  • Save Your Tonsils
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  • Food for Aging
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  • Green for Life
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  • Hot Water Cure
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  • Protect Your Teeth
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  • Why People are Sick
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  • Healing for the Sick
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  • Protect Your Eyesight
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  • Heal Eye Problems
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  • Mucusless Diet
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  • Not Stored in Fridge
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  • Natural Remedies
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  • The Danger of Wireless
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  • Books You Need in Life
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  • AGNI the General
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  • Cancer
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  • Cancer Heals - 48 Hrs.
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  • Dr. Null and Dr. Lodi
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  • Toxic Laundry
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  • Drinking With Meals
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  • 🌿 L O S E W E I G H T
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  • How to Lose Weight
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  • Lose Weight / 2
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  • Pure and Simple / 1
  • Pure and Simple / 2
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Food Combining
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  • Fat and Sugar
  • 80 - 10 - 10 Diet
  • Danger of Sugar & Fat
  • Help for PCOS
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  • 🌿 O I L
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  • Stop Heating Oil
  • Cooking Without Oil
  • Olive Oil is Bad for You
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  • World Health Retreats
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Avoid Natural Flavors
  • GMO Food
  • Glyphosate
  • H2o / Sodium Fluoride
  • Poison of the Century
  • Silent Killer / MSG
  • Sugar / Bitter Truth
  • Sore Throat - Use Zink
  • Vitamin D
  • 5 LOX - Lethal Enzyme
  • What are Prions?
  • Worst Ingredient ...
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  • Funny French Videos
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  • What is GcMAF?
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  • End of Mental Illness
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  • Extremely Dangerous
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  • World's 6 Best Doctors
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  • Autoimmune Disease
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  • Benefits of Oranges
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  • Miracle of Cucumber
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  • DHA Deficiency
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  • Danger of Vinegar
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  • Extremely ​Toxic
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  • What are Lectins?
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  • How to Make Kefir
  • Coconut Kefir
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Global Intoxication
  • Suicide Cult
  • Snitch Culture
  • The Hidden Truth
  • War Against Marriage
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  • What is a Virus?
  • Dr. Lanka - VIRUS
  • Dr. Lenkei - The Virus
  • AN URGENT VIDEO!
  • The mRNA Vaccination
  • This is Not a Vaccine
  • Science
  • The Invisible Rainbow
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • 🌿 J U I C I N G
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  • Celery Juice
  • Medical Medium
  • Medical Medium Book
  • The Miracle of Juicing
  • Juicers / Blenders
  • Juicing - Jay Cordich
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  • 🌿 🌿 🌿 🌿 🌿 🌿
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  • Linus Paulig
  • Vitamin C
  • Cancer & Vitamin C
  • Dr. Hoffer's Vitamins
  • 6000 x Vitamin C
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  • Astaxanthin
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  • Truth About Cancer
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  • Danger of PLASTIC
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  • Unsafe at Any Meal
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  • Hybrid Foods
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  • Health Videos
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  • MMS
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  • Coffee /Alcohol / Brain
  • Coffee / Deadly Poison
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  • Coca Cola and Soda
  • The Result of Cooking
  • McVegan Burger
  • Avoid Alzheimer
  • Alzheimer's and Prion
  • Worse Than Cigarettes
  • Everyone is Allergic
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  • Iridology
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  • Uplifting Music
  • The Best of Kuranesh
  • The Habit
  • Friend of the Animals
  • Just a Mother
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  • Bio Superfood
  • Power of Q 96
  • What the Health
  • Bragg Aminos / Poison
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  • Super Nutrition
  • Banana / Miracle Fruit
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  • Cure for Headache
  • Diet for Acne
  • High Doses / Vitamin D
  • Research on Aging
  • Repair Your DNA
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  • Cure for Mental Illness
  • Mental Health
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  • The Story of My Life
  • The Tombstone
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  • Grandfather's Wisdom
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  • 🌿 D I A B E T E S
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  • Reverse Diabetes
  • Nutrition for Diabetes
  • What to Eat / Diabetes
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  • 🌿 B E A U T I E S
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  • Beauty of Character
  • Beauty of Children
  • Beauty of Kindness
  • Beauty of Women
  • The Beauty of Man
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  • Beauty of Animals
  • Beauty of Clouds
  • Beauty of Birds
  • Beauty of Desert
  • Beauty of Macro
  • Beauty of Winter
  • Beauty of Flowers
  • Unique Flowers
  • Poems
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  • 🌿 K I N D N E S S
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  • Kindness & Gratitude
  • Kindness & Swearing
  • Kindness & Generosity
  • Kindness / Individuality
  • Kindness & Happiness
  • Kindness and Freedom
  • Kindness & Love
  • Kindness in SPAIN
  • Kindness Quotations
  • Fairy Magic Songs
  • Just Play a Song
  • No Negative People
  • Paradox of Our Age
  • A Film for Peace
  • A Revolutionary Idea
  • Behind ​Pornography
  • Book of Kindness
  • Letter of Love
  • Libertà
  • Money and People
  • Poverty
  • Prayer for My Children
  • Videos on Kindness
  • Radiation of Kindness
  • Why Walk We Can Fly
  • Who Will Dare to Love
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  • Message of Peace
  • 365 Days for Travelers
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  • Homeless
  • Need or Greed
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  • Courageous Woman
  • Food of Kindness
  • Kindness Only
  • Universal Quotes Facts
  • Signs of the Times
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  • Divorce and Children
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  • 🌿 H A P P I N E S S
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  • Ho'oponopono
  • Key to Happiness
  • Happiness and Peace
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  • Happy Place on Earth
  • Happy Place on Earth 2
  • Trap of Materialism
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  • 🌿 H E A L T H
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  • 🌿 M O V I E S
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  • Our Daily Poison
  • Earthling
  • Food Inc. / Cowspiracy
  • Food Matters
  • Forks Over Knife
  • Health Videos
  • Thrive / Full Movie
  • Origins Movie
  • Powerful Speech
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  • Film About Life
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  • 🌿 C A N C E R
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  • Cure Cancer
  • Cure with Wheatgrass
  • Cancer... / Dr. Circus
  • Cancer Risk / At Home
  • Cancer & Vitamin C
  • Dr. Leonard Caldwel
  • Ginger & Cancer
  • Hot Dog = Cancer
  • Potato Chips
  • Thyme / Chamomile
  • 7 Top Cancer Foods
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  • Truth About Cancer
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  • 🌿 G R A S S / C U R E
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  • Miracle of Wheatgrass
  • 50 Reasons
  • Super Food Living
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  • 🌿 M A G I C A L
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  • 🌿 M A R K U S
  • R O T H K R A N Z
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  • Magical Recipe
  • Incredible P I Z Z A
  • Loose Weight / Markus
  • Heal Your Face
  • Heal Yourself 101
  • Edible Weeds
  • Raw Food Ideas
  • Miracles
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  • 🌿 H O W - T O
  • L O S E - W E I G H T
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  • How to Lose Weight
  • Loose Weight / Markus
  • Raw Food / Works
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  • World Peace Diet
  • The 80 - 10 - 10 Diet
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  • 🌿 W O R S T F O O D
  • 🌿 W H E A T / E T C .
  • G L U T E N F R E E
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  • Bread
  • Gluten Brain
  • Extreme Dangers
  • Food for Faster Aging
  • Is Wheat Poison?
  • Is Quinoa Gluten Free?
  • Is Corn Gluten-Free?
  • Leaky Guts Syndrome
  • Mental Health / Gluten
  • No Starch for Infants
  • Rice / High in Arsenic
  • Wheat Belly
  • Dark Side of Wheat
  • Worst Food # 1
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  • 🌿 R A W - F O O D
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  • Raw Food
  • Fully Raw Videos
  • Green Smoothies
  • Garden Diet
  • Raw Food Recipes
  • Goldenseal
  • Deception / Raw Juice
  • Naked Juice
  • Most Pesticides Food
  • Real Raw Food Canada
  • Tanny Raw
  • 30 x Nutrition
  • 10 Healthiest Fruits
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  • Avoid Acidity
  • Best Papaya
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  • 🌿 G R E E N - T H E
  • M I R A C L E - F O O D
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  • Green Smoothies
  • Green Smoothies / 2
  • Red Malabar Spinach
  • Is Kale a Miracle Food?
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  • 🌿 R E T R E A T S
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  • Puerto Rico - Healing
  • ECUADOR Paradise
  • Garden of Healing
  • Eden Home Resort
  • Raw Retreat Costa Rica
  • Rancho La Puerta
  • Dr. Sebi's Healing
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  • 🌿 C O F F E E
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  • Dr. Amen on Coffee
  • Dangers of Coffee
  • Side Effects of Coffee
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  • 🌿 C A C A O
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  • Dangers of Cacao
  • Cacao / 2
  • Carob
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  • 🌿 S U N L I G H T
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  • Sunlight the Miracle
  • Sungazing
  • Sunlight by Dr. Kime
  • Solar Civilization
  • Sunlight / Sungazing
  • Sabiduria Cosmica
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  • 🌿 M E A T
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  • Meat
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  • Five Poison in Meat
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  • Avoid Some Fish
  • Chicken
  • Food Inc.
  • A Powerful Speech
  • Hot Dog = Cancer
  • Meat of the Future
  • Beyond Vegetarianism
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  • 🌿 F A S T F O O D
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  • Extremely ​Toxic
  • Fast Food
  • Children & Junk Food
  • Fast Food Poison
  • French Fries
  • Is Subway Real Food?
  • McDonald”s Food USA
  • Mockery of Humanity
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  • 🌿 G M O
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  • What is GMO Food?
  • Glyphosate
  • Glyphosate News
  • GMO News
  • GMO and the DNA
  • 20 GMO Food
  • GMO Products
  • 1000 X Toxic
  • Please Wake Up!
  • Against Humanity
  • GMO Bans and Laws
  • GMO Corn
  • GMO & Russia
  • GMO Linked to Gluten
  • Health Ranger
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  • 🌿 A L U M I N U M
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  • Dark Side of Aluminum
  • Aluminum / Autism
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  • 🌿 C O O K W A R E
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  • Aluminum Cookware
  • Cookwares Danger
  • Crock Pots
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  • 🌿 G E O
  • E N G I N E E R I N G
  • C H E M T R A I L
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  • Reasons Behind
  • Geo Engineering / 1
  • Geo Engineering / 2
  • Geo Engineering / 3
  • Complete Theory
  • Climate Control
  • Chemtrail Material
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  • What Chemtrails Are
  • Vaccines / Chemtrails
  • Chemtrail Protection
  • Engineered Drought
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  • 🌿 S O L U T I O N
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  • Solution for Chemtrail
  • Population Control
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  • 🌿 M O R G E L L O N S
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  • Morgellons Disease
  • Morgellons / 2
  • Old Age
  • Harald Kautz - Vella
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  • 🌿 A R T I F I C I A L
  • I N T E L L I G E N C E
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  • Artificial Intelligence
  • Artificial Intelligence II
  • Black Goo
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  • 🌿 R A D I A T I O N
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  • 5G Cell Phone Dangers
  • Radiation
  • Radiation / West Coast
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  • 🌿 O R G A N I C
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  • Go Organic
  • Eating Organic
  • Culinary Nightmares
  • Eating Healthy / Mental
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  • 🌿 A V O C A D O
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  • Miracle of Avocado
  • Avocado / 2
  • Avocado SEED
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  • 🌿 C O C O N U T
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  • Miracle of Coconut
  • For Dental Health / 1
  • For Dental Health / 2
  • Why Palm Sugar?
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  • 🌿 M I R A C L E
  • F O O D
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  • Green Smoothies
  • Miracle of Greens
  • Miracle of Wheatgrass
  • Miracle of Wild Green
  • Is Kale a Miracle Food?
  • Miracle of Alfalfa
  • Miracle Root / Beet
  • Miracle of Cherry
  • Miracle of Fulvic Acid
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  • How to Make Kefir
  • Miracle Goat Milk
  • Miracle of Lemon
  • Walnut
  • 5 "Careful" Super Food
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  • 🌿 B A N A N A
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  • Miracle of Banana
  • Banana / Loose Weight
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  • 🌿 A L O E - V E R A
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  • Aloe Vera
  • Aloe Vera / 2
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  • 🌿 T O B A C C O
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  • Organic Tobacco
  • Cigarette Additives
  • Eating vs. Smoking
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  • 🌿 F R E E B O O K S
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  • Dr. Shelton / Free PDF
  • Books on Health
  • Tissue Cleaning
  • Diet by Design
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  • Anastasia
  • I Ching Book
  • Napoleon Hill
  • The Power of Now
  • The Power of Now / 2
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  • 🌿 H E A L T H
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  • Calm Nerves
  • Diet in Few Words
  • DOLLAR Stores ?
  • Canola Oil / Facts
  • Food for the Eye
  • Mitochondria
  • Moringa / Super Food
  • Natural Cures
  • Organic Sulfur
  • Sunlight
  • The Silent Ecocide
  • 92 Side Effects
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  • I M M U N I Z A T I O N
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  • Immunization
  • History of Medication
  • Untold Horrors
  • Vaccines / Chemtrails
  • Vaccination Via Air
  • Vaxxed
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  • 🌿 S. F L U O R I D E
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  • H2o / Sodium Fluoride
  • Sodium Fluoride / 2
  • Sodium Fluoride / 3
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  • 🌿 W A T E R
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  • Alkaline Water
  • Test for Fluoride
  • H2o Alkalinity
  • H2o Ionizers
  • How to Mineralize H2o
  • Fluoride Toxicity
  • Plastic Bottles & BPA
  • H2O / Empty Stomach
  • What Water to Drink
  • Water & Lemon Juice
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  • 🌿 C O C A - C O L A
  • S O D A S
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  • Coca Cola and Soda
  • Red Bull etc.
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  • 🌿 S U G A R
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  • Sugar / Bitter Truth
  • Aspartame
  • Aspartame Poisoning
  • Cancer Risk to Millions
  • Erythritol / Sugar
  • Honey
  • Maple Sugar
  • Molasses
  • Why Palm Sugar?
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  • 🌿 D E T O X
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  • Liver & Kidney Cleanse
  • Tissue Cleaning
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  • 🌿 A S T H M A
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  • Asthma
  • Breathing
  • Replace Prednison
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  • 🌿 H E A L I N G
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  • Alzheimer, Arthritis / 1
  • Arthritis / 2
  • Food for Inflammation
  • Ear Infection
  • Heartburn
  • Irritable B. Syndrom
  • Prions & Alzheimer
  • Shingles
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  • 🌿 D E N T I S T R Y
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  • Dental Health / 1
  • Dental Health / 2
  • Magnesium for Teeth
  • Root Canal
  • Toxic Teeth
  • What is Wrong
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  • 🌿 D A N G E R S
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  • Dangers of Cocoa
  • Danger of Grapes / 1
  • Dangers of Microwave
  • Dangers of Night Shade
  • Dangers of Salt
  • Potato
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  • Dangers of Soy
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  • Grapefruit/Medication
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  • Onion Toxicity
  • Toxic Garlic
  • 10 Top Poisonous Food
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  • 🌿 M I L K
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  • Truth about Milk
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  • 🌿 T O X I C F O O D
  • A D D I T I V E
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  • Our Daily Poison
  • Toxic Food Additives
  • Toxic Pizza
  • Pesticide in Citrus
  • Poison on Your Platter
  • Toxic Light Bulbs
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  • 🌿 W E L L N E S S
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  • Iridology
  • Maggot Therapy
  • Stool Examination
  • Over 1000
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  • 🌿 C O S M E T I C S
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  • Dangers of Make-Up / 1
  • Dangers of Make-Up / 2
  • Natural Cosmetics
  • Toxic Cosmetics
  • Heal Your Face
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  • 🌿 C H I L D R E N
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  • Dr. Mendelson
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  • 🌿 MENTAL - HEALTH
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  • 🌿 MIRACLE of NIACIN
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  • Dr. D. G. Amen Clinic
  • Niacin / Mental Illness
  • Niacin / Vitamin B3
  • Niacin Deficency
  • Schizophrenia
  • Real Story of Niacin
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  • Lithium Orotate
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  • Anxiety
  • Anxiety / 2
  • Can Autism Be Cured
  • Gut and Mental Illness
  • Heal Depression
  • Help for Mental Illness
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  • Dr. Abram Hoffer
  • Dr. Hoffer's Vitamins
  • Dr. Andrew Saul Videos
  • Shocking Effects
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  • Mental Health / Gluten
  • Mental Health & Wheat
  • Medication Withdrawal
  • List of SSRI Medication
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  • 🌿 V I T A M I N S
  • M I N E R A L S
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  • Ascorbic Acid / Avoid It
  • Calcium Supplement
  • Vitamin C
  • Vitamin K2
  • Vitamin D / Grounded
  • Magnesium / 1
  • Magnesium / 2
  • Niacin / Vitamin B3
  • Niacin Deficency
  • Niacin / Mental Illness
  • Selenium
  • Real Story of Niacin
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  • 🌿 E X E R C I S E
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  • Benefits of Trampoline
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  • 🌿 G A R D E N I N G
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  • Starvation is Over
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  • Back to Eden
  • Better than Organic
  • Organic Gardening
  • Secret of Eldorado
  • $300 Greenhouse
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  • 🌿 G E N E R A L
  • I N F O R M A T I O N
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  • Paul Harvey / 1965
  • Art
  • Charlotte Iserbyt
  • Educational / Hand
  • Free Energy
  • Food Contains Nanite
  • Golden Ratio
  • Fibonacci Numbers
  • How to Tip
  • Home Sweet Home
  • How to Grow Rich
  • Hunza People
  • Ice Cube Effect
  • Kellogg
  • Kundalini Rising
  • Long Hair
  • More Than Reality
  • Sad Story
  • The Universe
  • Valhalla Culture
  • World Toughest Job
  • 8 Toxic People
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  • No More Prednison
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  • 🌿 F L O W E R S
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  • Flowers Unimaginable
  • Rózsa Özön
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  • 🌿 M U S I C
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  • Panflute Collection
  • Around the World
  • Beauty of Music
  • Carlo Gallozzi - Music
  • Child / Anak
  • Encouragement
  • Kitaro - Music
  • Libertà - Italian
  • Lona - Music
  • Michele Ippolito
  • Music
  • Music for Anxiety
  • Music 2 / Beethoven
  • Secret Garden - Music
  • Miel de Booton / Music
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  • Andreea Petcu - Music
  • Michel Pépé
  • Steve McDonald
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  • 🌿 H I S T O R Y
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  • Ancient Mystery
  • Chinese Wisdom
  • Dragonology
  • The Future
  • The Great Controversy
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  • 🌿 I N T E R V I E W S
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  • Simon Parkes
  • Harald Kautz - Vella
  • Harald Kautz - Vella / 2
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  • 🌿 ENTERTAINMENT
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  • Entertaining Videos
  • Humorous
  • Talent Shows
  • Treasures of Info.
  • The Snake
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  • Consciousness
  • Freedom of Speech
  • Law of Attraction
  • Simple Truth Movies
  • 45 Wisdom for Man
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  • Mucusless Diet
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  • 🌿 P R O B I O T I C
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  • Coconut Yoghurt
  • Cultured Food Life
  • Probiotic / BB 536
  • How to / Kombutcha
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  • 🌿 K E F I R
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  • History of Kefir
  • The Value of Kefir
  • How to Make Kefir - 2
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  • Sun Light Lamp
  • Sleeping
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  • Dr. Mercola
  • Green Med Info
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  • Clean Your Arteries
  • Clean the Mercury
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  • Calcium Removal
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  • 🌿 A N T I - A G I N G
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  • Secret of Long Life
  • Anti Aging Diet
  • Elder Action
  • Inflammation of Aging
  • Telomere / Anti Aging
  • Young Again
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  • Monoatomic Gold
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  • Senior Discount
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  • 🌿 MISCELLANEOUS
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  • Age of Treason
  • Articles / Whole Food
  • Chia Seed
  • Contaminated
  • Doctor Yourself . Com
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  • Epson Salt
  • FODMAP Food List
  • For Beautiful Hair
  • Heal Gout Naturally
  • Health Science
  • Iodine
  • Iron Absorption
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  • Miracle Treasure Book
  • Pictures With Meanings
  • Points of Diseases
  • Rice / Tomato / Potato
  • Rife Machine
  • Today's Worst Disease
  • Future Vaccination
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  • 🌿 M I X E D / I N F O
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  • Food Craving
  • Friends
  • Frequency 432 Hz
  • Hydrogen Peroxid
  • Improve Your Vision
  • Improve Your Vision /2
  • Books
  • How to Make Oetmeal
  • STEVIA DANGER
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  • Life Expectancy Test
  • Carl Blechen
  • Never Buy New Battery
  • Something Deadly
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  • 🌿 B E A U T I F U L
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  • Beauty of Trees
  • Beauty of Nature
  • Nature Videos
  • Unique Pictures
  • Unusual Pictures
  • Act of Kindness
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  • How to Stop Bed Bugs
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  • Lou Corona
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  • Anti Inflamatory
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  • Aloe Vera for Cancer
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  • Craiglist Check Scam
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  • Legal Shield
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  • Bentonite Clay
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  • Niner Simeon
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  • Colors
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  • GMO Potatoe Alert
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  • Amazing Result of C60
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  • Target is Humanity
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  • Surviving in Russia
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  • Meridian
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  • Danger of Products
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  • Pelvic Prolapse
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 Alzheimer's and Parkinson's

​Disease 
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What is Prion?

('protein aceous infectious particle'​)

Prion is a term first used to describe the mysterious infectious agent responsible for several

neurodegenerative diseases found in humans and in mammals.


Prions can be transmitted,

possibly by eating meat and dairy product (cow, sheep and goat)

and certainly by inoculation either directly into the brain or into skin and muscle tissue.


https://www.scientificamerican.com/article/what-is-a-prion-specifica/​
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Are Prions Behind

All Neurodegenerative Diseases?


Evidence mounts that chain reactions involving toxic proteins link in

 Alzheimer’s, Parkinson’s and more.
​

https://www.scientificamerican.com/article/are-prions-behind-all-neurodegenerative-diseases1/
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Is Alzheimer's Disease Caused by a Prion?
​
Now, a study in Nature reveals the first evidence for human-to-human transmission of the misfolded proteins that underlie the pathology of Alzheimer's disease. ...

​Some of these samples were contaminated with prions that caused certain patients
​to develop Creutzfeldt-Jakob disease (CJD), a rare and fatal brain disorder.
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Is Alzheimer's Contagious?

In the 25 years that John Collinge has studied neurology, he has seen hundreds of human brains.
But the ones he was looking at under the microscope in January 2015
were like nothing he had seen before ...


... for Collinge, this led to a worrying conclusion: that the plaques might have been transmitted, alongside the prions, in the injections of growth hormone—the first evidence that Alzheimer's could be transmitted from one person to another.

https://www.scientificamerican.com/article/the-red-hot-debate-about-transmissible-alzheimer-s/​
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Do Vegans Get Alzheimer's?

Recent research suggests that Alzheimer's disease, like heart disease and strokes, is linked to the saturated fat, cholesterol, and toxins found in meat and dairy products.

​Studies have shown that people who eat meat and dairy products have a greater risk of developing Alzheimer's disease than do vegetarians.
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Prion is

"Protein Aceous Infectious Particle"
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Alzheimer's Science Shocked

by Discovery That Key Protein Behaves

​Like an Infection


Dana Dovey,

Newsweek Thu, Jan 11 1:26 PM EST ​

This article was first written by Newsweek
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Alzheimer’s disease may spread though the brain like an infection, a new study has found. Most scientists agree that tau proteins are one of the main causes of Alzheimer's and now, for first time, researchers observed the protein in real-time as it spread throughout neurons in the brain. The finding may fundamentally change how we think about Alzheimer’s disease, and in turn affect how we treat the disorder as well.

The findings published online in the journal, Brain appear to support the theory of transneuronal spread, IFL Science reported. Tau proteins normally aid in brain function, but can become defective or collapse and then form tangles, which may lead to the onset of Alzheimer's. The transneuronal spread theory suggests that the proteins spread just like an infection and areas with the largest build-up of proteins will then pass these on to the surrounding connections. While this idea has been shown in mice, this is the first time researchers have seen it happening in human brains.

Related: Brains Age Suddenly At Around 40, But This Gene May Stop It And Even Prevent

Alzheimer's Along The Way 

​
The researchers were able to study the brains of AD patients in real time. 

CRISTINA QUICLER (Photo credit should read CRISTINA QUICLER/AFP/Getty Images

The Above Picture


Trending: What Are Fast Radio Bursts and Why Do They Look Like Aliens?

Related: New Approach May Allow Doctors To Attack Alzheimer's Protein 

"This is an important step on the journey towards effective treatments for Alzheimer's disease," lead author, Dr. Thomas Cope from the Department of Clinical Neurosciences at the University of Cambridge, told Newsweek. "It implies that treatments to prevent the spread of abnormal tau between neurons might be effective in humans."

Most of what we know about Alzheimer's is derived from looking at the brains of dead patients, but in this new study, the research took a novel approach by peering into the brains of still-living patients using a technique called positron emission tomography.

This involves injecting the patients with a radioactive substance that specifically binds to tau proteins and then using a scanner to see these proteins' movements. The researchers monitored the brains of 17 Alzheimer's patients and results gave them a rudimentary idea of how tau proteins moved and behaved.

Understanding how Alzheimer's develops is critical to treating it. If doctors know how the disease spreads throughout the brain then they may be able to develop ways to slow down this spread or even stop it completely.

Don't miss: Pelican ‘Assassin’ Spiders Discovered in Madagascar Are Stealthy Ninjas With Beak-like Fangs

For now, more research is needed before this finding can have clinical applications and potentially help treat an illness that affects 5.5 million Americans and counting.

"The ultimate goal of us all is to prevent this devastating illness from causing the widespread brain damage that leads to dementia and loss of independence," added Cope. 

This article was first written by Newsweek
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What Disease is Caused by a Prion?

Human Prion Diseases
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  • Creutzfeldt-Jakob Disease (CJD)
  • Gerstmann-Sträussler-Scheinker disease (GSS)
  • Fatal Familial Insomnia (FFI)
  • Kuru.
  • Scrapie.
  • Bovine Spongiform Encephalopathy (BSE) or "Mad Cow Disease"
  • Creutzfeldt-Jakob Disease (CJD)
  • Variant Creutzfeldt-Jakob Disease (vCJD)
  • http://www.iflscience.com/health-and-medicine/new-prion-disease-raises-questions-about-whether-alzheimer-s-and-parkinson-s/
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KuruHumans

Creutzfeldt–Jakob disease 

Variant Creutzfeldt–Jakob disease [7]

Gerstmann-Sträussler-Scheinker syndrome
​
​
Fatal familial insomnia
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Non - Human Prion Diseases

Transmissible mink encephalopathy 
​
Chronic wasting disease Elk, 

Bovine spongiform encephalopathy 

Feline spongiform encephalopathy

Exotic ungulate encephalopathy
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https://www.thermofisher.com/blog/food/prion-disease-and-the-safety-of-our-food-supply/​
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Prion Disease and the Safety of our Food Supply - Examining

Brain Diseases May Spread from Animals to Humans More Easily than.

The Basics of Mad Cow Disease - WebMD
Prion Diseases | Johns Hopkins Medicine Health

Risk for Travelers | Variant Creutzfeldt-Jakob Disease, Classic (CJD

A case of prion disease acquired from contaminated beef - Virology

Cannibalism: When People Ate People, A Strange Disease Emerged

Prion disease found lurking in deer muscle

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http://www.cfsph.iastate.edu/Factsheets/pdfs/scrapie.pdf

http://www.eradicatescrapie.org/About%20Scrapie/Fact%20Sheet.html


http://www.tennesseemeatgoats.com/articles2/scrapie.html​
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https://www.ncbi.nlm.nih.gov/pubmed/9810774
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Prionoses--neurodegenerative diseases caused by prions,

offectious proteinaceous molecules.


Ferencík M1, Novák M, Mikula I, Sokol J. / Author information​
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Prionoses are a group of human and animal neurodegenerative diseases caused by prions, infectious pathogens that differ from bacteria, fungi, parasites, viroids, and viruses. Despite intensive searches over the past three decades, no nucleic acid has been found within prions and considerable experimental data argue that prions are composed exclusively of proteins (glycoproteins).

Normal prion protein (PrPC) is encoded by a gene present in all nuclear cells of humans and other mammals but is constitutively expressed mainly in neurons. PrPC is protease sensitive and nonpathogenic but it can be modified to the pathological and protease resistant form designated PrPSC which is essential for infectivity.

Prion diseases are manifested as infectious, genetic, or sporadic disorders and are also named as transmissible spongiform encephalopathies (TSE). TSE culminate with a progressive and fatal degeneration of the CNS. The human prionoses include Creutzfeldt-Jakob disease (CJD), kuru, Gerstman-Sträussler-Scheinker syndrome (GSS), and fatal familial insomnia (FFI). In mammals, more than 15 different species have been described to suffer from prion disorders till now.

Scrapie of sheep and goats is the oldest and the most studied of the prion diseases. Bovine spongiform encephalopathy (BSE) and transmissible mink encephalopathy are thought to result from the feeding of scrapie-infected animal products, whereas BSE has been identified in transmission to mice, domestic cats, two exotic species of ruminant, and monkey.

More than 20 cases of clinically and pathologically atypical form of CJD, referred to as "new variant" CJD (vCJD) have been recognized in unusually young people in the United Kingdom. There is a strong evidence that the same prion strain is involved in both BSE and vCJD.

It suggest the breaking of species barrier which results by spreading of BSE to humans, putatively by dietary exposure. Understanding the function of prion proteins and their modification to the pathological form may give new insight into the etiologic and pathogenic mechanisms also other diseases caused by aberrant proteins, including Alzheimer' disease, amyotrophic lateral sclerosis, and Parkinson's disease. (Tab. 4, Fig. 3, Ref. 76.).
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The word prion comes from an amalgam

​of pro_teinaceous in_fectious particle. AJ Cann/Flickr, CC BY-NC
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http://www.iflscience.com/health-and-medicine/new-prion-disease-raises-questions-about-whether-alzheimer-s-and-parkinson-s/
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New Prion Disease Raises Questions 

About Whether Alzheimer’s And Parkinson’s 

​Could Be Infectious
HEALTH AND MEDICINE

PRION DISEASES ARE A RARE CLASS OF BRAIN DISORDERS

THAT ARE TRANSMISSIBLE BETWEEN ANIMALS OF ANY SPECIES, INCLUDING HUMANS.

 DJNEIGHT/FLICKR, CC BY-NC-ND

Research published last week has identified the first new human prion disease in 50 years. The paper’s lead author, Stanley Prusiner, who won the Nobel prize in 1997 for his discovery that Creutzfeldt-Jakob disease (CJD) could be transmitted by a “misfolded” protein, says this new disease is also potentially infectious.

Prion diseases are a rare class of brain disorders that are transmissible between animals of any species, including humans. The archetypal such disease is kuru, which spread through cannibalistic rituals in the Eastern Highlands of Papua New Guinea.

Rare And Deadly

Kuru affected mostly women and children of the Fore tribe, who ate brains and spinal cords of deceased relatives, and subsequently developed body tremors, balance problems and slurred speech. There’s no cure for kuru and sufferers always died. But it no longer strikes as cannibalism in the region has been eliminated.

Other prion diseases include scrapie in sheep and goats and bovine spongiform encephalopathy (BSE) in cows. When transmitted to humans during the “mad cow disease” outbreak in Europe, BSE resulted in variant CJD (vCJD).

The newly described addition to the prion disease canon, Shy-Drager syndrome (SDS) or multiple system atrophy (MSA), was first recognised in the early 1960s and has many features in common with Parkinson’s disease.

The most important of these is that a protein known as α-synuclein (α-syn) accumulates in the brain, in both Parkinson’s and SDS/MSA. This accumulation is very similar to what happens in CJD, where the prion protein (PrP) accumulates, and also in Alzheimer’s disease and other dementias, where two types of proteins, known as amyloid beta (Aβ-amyloid) and tau, build up in the brain.

The clumps and tangles of these various aggregated proteins cause neurons to degenerate and die. This is a cumulative process which takes between months and decades to manifest as overt disease.
In fact, many of the neurodegenerative diseases of the ageing brain are associated with the accumulation and deposition of specific proteins.

It has long been suspected that neurodegenerative diseases in general may all ultimately be caused by this process of proteins getting caught in the wrong process, and misfolding.

This misfolding sets off a cascade of events: the proteins oligomerise (a number of identical molecules join together); accumulate; nucleate (form a nucleus or centre); polymerise (combine to build a structure with its components); self-replicate; and eventually, propagate and spread throughout the brain. Many of these protein changes also occur in the usual food cooking process (aggregation of proteins caused by heating) or food preparation (the solidification of proteins in the refrigerator).

Finally, some but not all of these misfolded proteins gain the ability to be transmitted between people and animals. In fact, the word “prion” was coined by Prusiner in 1982 to describe this property of a pro_teinaceous in_fectious particle. And we don’t yet know of ways to easily “dis-infect” or kill these proteins. All kinds of chemicals that kill bacteria and viruses do not harm prions.

Infectious Proteins

Scientists have always kept – and still do – an open mind about whether Alzheimer’s disease and other neurodegenerative conditions are transmissible. We’ve known since the early 1960s that amyloid fibrils – the accumulations of Aβ-amyloid in the brain - are self-propagating entities.
In diseases involving amyloid protein, the “amyloid enhancing factor”, which causes the disease to progress, is thought to be amyloid itself. In other words, the amyloid is self-replicating and makes copies of itself exponentially.

Scientists have always kept an open mind

about whether Alzheimer’s disease

and other neurodegenerative conditions are transmissible. 

Isaac Mao/Flickr, CC BY

We know that the Alzheimer’s disease-causing human Aβ-amyloid can cross-seed Aβ-amyloid accumulation in genetically susceptible rodents. Mice carrying an unstable and genetically modified human protein can then be “infected” by giving them a dose of the human abnormal protein. 
​But there’s still no direct evidence that Alzheimer’s disease is transmissible between people.

Working out whether SDS/MSA is transmissible, at least from humans to genetically susceptible transgenic cell and rodents, is the first step in testing if it’s transmissible from humans to primates, or indeed among people.

As a precautionary measure, the authors of the paper warn we should now take additional safety precautions in the neurosurgical clinics where deep brain stimulation is used to control the tremors caused by Parkinson’s disease. Because of the overlap in symptoms and signs of Parkinson’s with SDS/MSA, it’s likely that some people with the newly described disease have been treated by deep brain stimulation.

It’s important to ensure that cross-contamination of neurosurgical equipment doesn’t occur because we don’t want to inadvertently transmit a disease between humans. Using disposable stimulation electrodes, for instance, will be mandatory in the future. Similar concerns have already been raised about other neurodegenerative illnesses, such as diseases involving misfolded tau protein, which cause frontotemporal dementia.

With the publication of this paper, the spectrum of prion diseases has been enlarged, perhaps considerably. But until it becomes possible to evaluate the role of intra-species transmission, SDS/MSA will have to remain in the category of “hypothetically transmissible to a genetically susceptible recipient”.

It’s premature to classify it as being the same as CJD, which is clearly transmissible within and between species. That has been made apparent by the mad cow saga, which still has years to run due to the long latency from prion infection to overt disease.

Colin Masters, Distinguished Florey Fellow, The Florey Institute of Neuroscience and Mental Health
This article was originally published on The Conversation. Read the original article.
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https://www.zmescience.com/medicine/genetic/papua-new-guinea/
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