_______________________________________________________________________________
Natural Treatment for Bipolar Disorder
and Alzheimer’s Ignored!
Dr. Michelle Kmiec 12 Comments Oct 22, 2014
Why Lithium Orotate is Superior
and SAFER than Lithium Carbonate
http://www.onlineholistichealth.com/lithium-orotate-misleading-research/
(Revised from July, 2014)
Audio By: Dr Michelle Kmiec - Natural Treatment for Bipolar Disorder and Alzheimer's Ignored!
You may find references to a 1979 study on the internet comparing lithium carbonate and lithium orotate regarding kidney function and safety.
There have been many studies since, but pro-pharmaceutical advocates love to spew out faulty data arguing its validity.
So let’s be very clear once and for all, regarding the truth behind this highly quoted study.
It’s all about Bioavailability.
Lithium whether prescription or non-prescription is in the form of a salt. The lithium ion is attached to salts, like carbonate from carbonic acid, citrate from citric acid, or orotate from orotic acid. So, the idea when taking any form of lithium, is getting the elemental lithium, which is what is effective, to be absorbed by the body.
Is Elemental Lithium Toxic?
Lithium, being a trace mineral, is only tolerated in small amounts. In fact, we need small amounts of all trace minerals for our health. However, just like with any substance, including water, too much can be toxic.
So the trick is to give the body what it needs, thus improving health, but without giving too much so as to be toxic.
Lithium has been long known for it healing properties regarding mental conditions such as bi-polar and manic disorders. In the 1940’s lithium chloride was used as a substitute for table salt, but after some reported deaths due to toxic effects, it was promptly prohibited.
This has lead many to “logically” believe that lithium chloride is toxic, but this is not necessarily true. People aware of the effect of lithium on mood, actually used the salt in excess; of course, at the time it was unknown that the salt was, in fact, toxic in large amounts. Lithium chloride seems to have been toxic due to the poor bioavailability of the carrier salt that the lithium was attached to; in this case chloride.
Lithium chloride, just as with sodium chloride (table salt), is a necessary element we need for health. However, as we all are well aware, table salt when used in excess can have extremely harmful effects on our health. So the balance is what we need to find.
Just as with lithium chloride, lithium carbonate can become toxic for the same reason – poor bioavailability. Trying to achieve the amount of lithium needed for the desired health effects without damaging the body in the process is a major concern, and is why those who take this version of lithium must have their kidney function tested often.
This is where lithium orotate come in.
Safe, yet Ignored, Lithium OrotateOrotates, discovered by Dr. Hans Nieper, were found to be a component of natural electrolyte carriers designed for distributing minerals throughout the body.
Based on Dr. Nieper’s observations of cells, he concluded that molecules of minerals attached to an orotate carrier can pass through cell membranes intact without breaking apart into their component ions.
This was a ground breaking discovery, because it was found that the respective ions of the mineral could be released at specific membrane sites within the cell. This is what is known as the bioavailability of the orotate carrier of minerals and it has since been applied to calcium, magnesium, zinc, and lithium.
Why that 1979 Study was FlawedThe study was simple:
There were 3 groups of rats; one group of rats was injected with lithium carbonate, one group was injected with lithium orotate, and the third group (the control group) was injected with sodium chloride (salt).
All injections were of equal amounts.
Now remember that the premise of lithium orotate is that less amounts of elemental lithium is required to achieve the same effects of lithium carbonate.
The results of the study concluded that kidney function was lowered in the rats that were given lithium orotate than those that were given lithium carbonate. Based on this study, they advised against the use of lithium orotate for treatment in patients.
Well, yikes for lithium orotate lovers, as well as for ‘natural is better’ advocates…
…or is it?
There was a major flaw in the study, and the flaw was that all the injections were of equal amounts. Again, the whole idea of lithium orotate is that less is needed to achieve the effect of the lithium carbonate, making it a safer, and more effective option.
Again, it’s all about the elemental absorbability of the lithium.
Briefly: Let’s take a look at typical lithium dosages of both lithium carbonate and lithium orotate that is required to achieve the same health effect:
_______________________________________________________________________________
300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
120 mg Lithium Orotate tablet contains 4.6 mg elemental lithium.
For Bipolar you need to take 60 to 80 mg Lithium Orotate.
8 x 4.6 = 36.8 / 8 in the Morning / 8 in the Evening. / 80 mg is 16 tablets.
60 mg is 6 tablets.
6 in the Morning / 6 in the Evening. / 60 mg is 12 tablets.
_____________________________________________________________________________
Can you see the tremendous flaw of the study unfolding?
If equal amounts of the lithium orotate and lithium carbonate were used in the study, using the amount of lithium carbonate as the standard amount, then an equal amount of lithium orotate would be anincredible overdose in comparison.
In simple terms, lithium orotate is absorbed faster than lithium carbonate so lower doses of lithium orotate are need to achieve the same effect of lithium carbonate.
So actually, this study proved the effectiveness of lithium orotate over lithium carbonate by the very result of the lower renal function at the same dosage.
Real scientists (a real scientists is a person in the search of knowledge and truth, not for special interest) would have realized this obvious result, which in comparison, the lithium orotate was 700% in excess to that of lithium carbonate!
Then finally! The flaw did become apparent to other scientists who stepped-up and preformed a follow-up study. Kling, Manowitz and Pollack concluded:
“This data suggest the possibility that lower doses of lithium orotate than lithium carbonate may achieve therapeutic brain lithium concentrations and relatively stable serum concentrations.”
Dr. Ward Dean, M.D said it best,
“Prescription lithium is poorly absorbed by the cells, where it needs to be to do its job. Because it is so poorly absorbed, blood levels need to be fairly high to “drive it into the cells.” Unfortunately, these “therapeutic” blood levels are dangerously close to the toxic level. That’s why patients on prescription lithium need to be carefully monitored. The level needs to be high enough to push the lithium into the cells, but not too high to pickle the kidneys.
However, with lithium orotate, it is not necessary to reach “therapeutic” blood levels, because it seems to go right into the cells where it belongs, and where it can do its intended job. I think a more effective way to determine whether lithium orotate is working, and whether an adequate dose has been prescribed, is to monitor the patient. Usually, asking them how they feel is enough. The effects are evident to the patient, as well as to the people around him. I think doing a blood test when taking lithium orotate is a waste of blood.”
Well thank you Dr. Dean! Maybe now we are getting somewhere…
… deep sigh…think again!
Despite the Research, the Blinders Stay On!
Despite the research and potential applications of this impressive mineral, the conventional medical establishment won’t open their eyes to anything that sways them away from their deep dogmatic position. To prove this allegation.
An article from the National Institute on Aging entitled, “Lithium Shows Promise Against Alzheimer’s in Mouse Model” found that lithium blocked an enzyme crucial to the formation of Alzheimer’s plaques.
“In mouse neurons expressing amyloid precursor protein, lithium significantly reduced production of beta amyloid. A therapeutic dose of lithium also markedly reduced beta amyloid production in an animal model of Alzheimer’s disease — mice carrying mutations that are known to cause inherited Alzheimer’s disease in humans.”
This is exciting news in the fight against this debilitating disease, right? Yet these same scientists “determined” the following:
“Although widely used to treat bipolar disorder, lithium’s propensity to cause side-effects may limit its use in older people, who are more susceptible to Alzheimer’s disease,” cautioned Peter Klein, M.D., University of Pennsylvania School of Medicine, who led the research team, which was funded by the National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA).
But they did shed some perceived light:
“Lithium also protects neurons from stimuli that trigger programmed neuronal cell death in Alzheimer’s disease. Pending development of new medications that target the enzyme, the researchers suggest that lithium “might be considered for the prevention of Alzheimer’s disease, especially in younger patients with an inherited form of Alzheimer’s disease or Down’s syndrome.”
Why are so many “scientists” blind to the obvious time and time again?
I agree, wholeheartedly, that lithium carbonate can indeed cause problems in older patients, especially when using at therapeutic dosages. However, why not use lithium orotate instead, which has no side-effects at therapeutic levels?
Contradiction in Terms!The National Institute on Aging tag line is, “Leading the federal effort on aging research.”
Really? When did their research become so selective and inclusive?
There are those who feel there is a conspiracy against finding cures of major diseases and health conditions, because if cures were really found, the billions of dollars lost to the endless assembly line of pharmaceuticals would be unthinkable.
After all the hours of research I have done regarding supplements, deficiencies, and our ever-increasing disease statistics, despite the all the pharmaceuticals, if it isn’t’ a conspiracy, then these scientists are truly doing an injustice regarding the search for knowledge and truth.
Scientists should be interested in researching ALL options and possibilities without bias. After all, isn’t that what our scientific method of evidence based medicine was created to accomplish?
I personally prefer the name brand Advanced Research. You can purchase lithium orotate from many different websites. Here is a useful link that breaks down the different places that sell lithium orotate and their prices.
and Alzheimer’s Ignored!
Dr. Michelle Kmiec 12 Comments Oct 22, 2014
Why Lithium Orotate is Superior
and SAFER than Lithium Carbonate
http://www.onlineholistichealth.com/lithium-orotate-misleading-research/
(Revised from July, 2014)
Audio By: Dr Michelle Kmiec - Natural Treatment for Bipolar Disorder and Alzheimer's Ignored!
You may find references to a 1979 study on the internet comparing lithium carbonate and lithium orotate regarding kidney function and safety.
There have been many studies since, but pro-pharmaceutical advocates love to spew out faulty data arguing its validity.
So let’s be very clear once and for all, regarding the truth behind this highly quoted study.
It’s all about Bioavailability.
Lithium whether prescription or non-prescription is in the form of a salt. The lithium ion is attached to salts, like carbonate from carbonic acid, citrate from citric acid, or orotate from orotic acid. So, the idea when taking any form of lithium, is getting the elemental lithium, which is what is effective, to be absorbed by the body.
Is Elemental Lithium Toxic?
Lithium, being a trace mineral, is only tolerated in small amounts. In fact, we need small amounts of all trace minerals for our health. However, just like with any substance, including water, too much can be toxic.
So the trick is to give the body what it needs, thus improving health, but without giving too much so as to be toxic.
Lithium has been long known for it healing properties regarding mental conditions such as bi-polar and manic disorders. In the 1940’s lithium chloride was used as a substitute for table salt, but after some reported deaths due to toxic effects, it was promptly prohibited.
This has lead many to “logically” believe that lithium chloride is toxic, but this is not necessarily true. People aware of the effect of lithium on mood, actually used the salt in excess; of course, at the time it was unknown that the salt was, in fact, toxic in large amounts. Lithium chloride seems to have been toxic due to the poor bioavailability of the carrier salt that the lithium was attached to; in this case chloride.
Lithium chloride, just as with sodium chloride (table salt), is a necessary element we need for health. However, as we all are well aware, table salt when used in excess can have extremely harmful effects on our health. So the balance is what we need to find.
Just as with lithium chloride, lithium carbonate can become toxic for the same reason – poor bioavailability. Trying to achieve the amount of lithium needed for the desired health effects without damaging the body in the process is a major concern, and is why those who take this version of lithium must have their kidney function tested often.
This is where lithium orotate come in.
Safe, yet Ignored, Lithium OrotateOrotates, discovered by Dr. Hans Nieper, were found to be a component of natural electrolyte carriers designed for distributing minerals throughout the body.
Based on Dr. Nieper’s observations of cells, he concluded that molecules of minerals attached to an orotate carrier can pass through cell membranes intact without breaking apart into their component ions.
This was a ground breaking discovery, because it was found that the respective ions of the mineral could be released at specific membrane sites within the cell. This is what is known as the bioavailability of the orotate carrier of minerals and it has since been applied to calcium, magnesium, zinc, and lithium.
Why that 1979 Study was FlawedThe study was simple:
There were 3 groups of rats; one group of rats was injected with lithium carbonate, one group was injected with lithium orotate, and the third group (the control group) was injected with sodium chloride (salt).
All injections were of equal amounts.
Now remember that the premise of lithium orotate is that less amounts of elemental lithium is required to achieve the same effects of lithium carbonate.
The results of the study concluded that kidney function was lowered in the rats that were given lithium orotate than those that were given lithium carbonate. Based on this study, they advised against the use of lithium orotate for treatment in patients.
Well, yikes for lithium orotate lovers, as well as for ‘natural is better’ advocates…
…or is it?
There was a major flaw in the study, and the flaw was that all the injections were of equal amounts. Again, the whole idea of lithium orotate is that less is needed to achieve the effect of the lithium carbonate, making it a safer, and more effective option.
Again, it’s all about the elemental absorbability of the lithium.
Briefly: Let’s take a look at typical lithium dosages of both lithium carbonate and lithium orotate that is required to achieve the same health effect:
_______________________________________________________________________________
- 300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
- 1 – 2 capsules TIB (3 times per day)
- Equals 180 – 360 mg of elemental lithium
- 100 mg of lithium orotate contains ~ 5 mg of elemental lithium
- 1 – 2 tablets TIB
- Equals 15 – 30 mg of elemental lithium
300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
120 mg Lithium Orotate tablet contains 4.6 mg elemental lithium.
For Bipolar you need to take 60 to 80 mg Lithium Orotate.
8 x 4.6 = 36.8 / 8 in the Morning / 8 in the Evening. / 80 mg is 16 tablets.
60 mg is 6 tablets.
6 in the Morning / 6 in the Evening. / 60 mg is 12 tablets.
_____________________________________________________________________________
Can you see the tremendous flaw of the study unfolding?
If equal amounts of the lithium orotate and lithium carbonate were used in the study, using the amount of lithium carbonate as the standard amount, then an equal amount of lithium orotate would be anincredible overdose in comparison.
In simple terms, lithium orotate is absorbed faster than lithium carbonate so lower doses of lithium orotate are need to achieve the same effect of lithium carbonate.
So actually, this study proved the effectiveness of lithium orotate over lithium carbonate by the very result of the lower renal function at the same dosage.
Real scientists (a real scientists is a person in the search of knowledge and truth, not for special interest) would have realized this obvious result, which in comparison, the lithium orotate was 700% in excess to that of lithium carbonate!
Then finally! The flaw did become apparent to other scientists who stepped-up and preformed a follow-up study. Kling, Manowitz and Pollack concluded:
“This data suggest the possibility that lower doses of lithium orotate than lithium carbonate may achieve therapeutic brain lithium concentrations and relatively stable serum concentrations.”
Dr. Ward Dean, M.D said it best,
“Prescription lithium is poorly absorbed by the cells, where it needs to be to do its job. Because it is so poorly absorbed, blood levels need to be fairly high to “drive it into the cells.” Unfortunately, these “therapeutic” blood levels are dangerously close to the toxic level. That’s why patients on prescription lithium need to be carefully monitored. The level needs to be high enough to push the lithium into the cells, but not too high to pickle the kidneys.
However, with lithium orotate, it is not necessary to reach “therapeutic” blood levels, because it seems to go right into the cells where it belongs, and where it can do its intended job. I think a more effective way to determine whether lithium orotate is working, and whether an adequate dose has been prescribed, is to monitor the patient. Usually, asking them how they feel is enough. The effects are evident to the patient, as well as to the people around him. I think doing a blood test when taking lithium orotate is a waste of blood.”
Well thank you Dr. Dean! Maybe now we are getting somewhere…
… deep sigh…think again!
Despite the Research, the Blinders Stay On!
Despite the research and potential applications of this impressive mineral, the conventional medical establishment won’t open their eyes to anything that sways them away from their deep dogmatic position. To prove this allegation.
An article from the National Institute on Aging entitled, “Lithium Shows Promise Against Alzheimer’s in Mouse Model” found that lithium blocked an enzyme crucial to the formation of Alzheimer’s plaques.
“In mouse neurons expressing amyloid precursor protein, lithium significantly reduced production of beta amyloid. A therapeutic dose of lithium also markedly reduced beta amyloid production in an animal model of Alzheimer’s disease — mice carrying mutations that are known to cause inherited Alzheimer’s disease in humans.”
This is exciting news in the fight against this debilitating disease, right? Yet these same scientists “determined” the following:
“Although widely used to treat bipolar disorder, lithium’s propensity to cause side-effects may limit its use in older people, who are more susceptible to Alzheimer’s disease,” cautioned Peter Klein, M.D., University of Pennsylvania School of Medicine, who led the research team, which was funded by the National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA).
But they did shed some perceived light:
“Lithium also protects neurons from stimuli that trigger programmed neuronal cell death in Alzheimer’s disease. Pending development of new medications that target the enzyme, the researchers suggest that lithium “might be considered for the prevention of Alzheimer’s disease, especially in younger patients with an inherited form of Alzheimer’s disease or Down’s syndrome.”
Why are so many “scientists” blind to the obvious time and time again?
I agree, wholeheartedly, that lithium carbonate can indeed cause problems in older patients, especially when using at therapeutic dosages. However, why not use lithium orotate instead, which has no side-effects at therapeutic levels?
Contradiction in Terms!The National Institute on Aging tag line is, “Leading the federal effort on aging research.”
Really? When did their research become so selective and inclusive?
There are those who feel there is a conspiracy against finding cures of major diseases and health conditions, because if cures were really found, the billions of dollars lost to the endless assembly line of pharmaceuticals would be unthinkable.
After all the hours of research I have done regarding supplements, deficiencies, and our ever-increasing disease statistics, despite the all the pharmaceuticals, if it isn’t’ a conspiracy, then these scientists are truly doing an injustice regarding the search for knowledge and truth.
Scientists should be interested in researching ALL options and possibilities without bias. After all, isn’t that what our scientific method of evidence based medicine was created to accomplish?
I personally prefer the name brand Advanced Research. You can purchase lithium orotate from many different websites. Here is a useful link that breaks down the different places that sell lithium orotate and their prices.
_______________________________________________________________________________
_______________________________________________________________________________
300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
120 mg Lithium Orotate tablet contains 4.6 mg elemental lithium.
For Bipolar Disorders you need to take 60 to 80 mg Lithium Orotate.
80 mg is 16 tablets.
8 x 4.6 = 36.8 / 8 in the Morning / 8 in the Evening.
60 mg is 6 tablets.
6 in the Morning / 6 in the Evening.
- 300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
- 1 – 2 capsules TIB (3 times per day)
- Equals 180 – 360 mg of elemental lithium
- 100 mg of lithium orotate contains ~ 5 mg of elemental lithium
- 1 – 2 tablets TIB
- Equals 15 – 30 mg of elemental lithium
300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
120 mg Lithium Orotate tablet contains 4.6 mg elemental lithium.
For Bipolar Disorders you need to take 60 to 80 mg Lithium Orotate.
80 mg is 16 tablets.
8 x 4.6 = 36.8 / 8 in the Morning / 8 in the Evening.
60 mg is 6 tablets.
6 in the Morning / 6 in the Evening.
Lithium Orotate 200 Tabs by Advanced Research
Advanced Research / Nutrient Carriers
Lithium Orotate
Item: ADR016
100 Tabs
$10.04
Lithium Orotate from Advanced Research (formulated specifically by Hans Nieper, M.D. of Hannover, Germany), features lithium combined with orotic acid to increase bioavailability. Lithium has been used for a variety of health applications for over a century.
This supplement—made in the USA—delivers 4.6 mg of elemental lithium per tablet.
Lithium Orotate
Item: ADR016
- Lithium Orotate from Advanced Research
- Formulated by Hans Nieper, M.D. of Hannover, Germany
- Delivers 4.6 mg of elemental lithium per tablet
100 Tabs
$10.04
Lithium Orotate from Advanced Research (formulated specifically by Hans Nieper, M.D. of Hannover, Germany), features lithium combined with orotic acid to increase bioavailability. Lithium has been used for a variety of health applications for over a century.
This supplement—made in the USA—delivers 4.6 mg of elemental lithium per tablet.
The Lithium Doctor
Warning!
For 3 minutes free consultation you need to tell Dr. Millar immediately,
that only for 3 minutes,
otherwise he just keep talking.
For 3 minutes free consultation you need to tell Dr. Millar immediately,
that only for 3 minutes,
otherwise he just keep talking.
Sometimes something so simple can change lives
and in this case,
lithium orotate just may be one of those things!
DR. MARK MILLAR shares what this natural, organic mineral does for our bodies and how it makes life better by just giving our body this supplement. Dr. Millar is a retired Chiropractor who has spent the last 3 years writing two books on the topic of a nutritional breakthrough for PTSD, Depression, Traumatic Brain Injury, suicide and Alzheimer's disease.
Dr. Millar was called to this mission by his personal experience suffering with bipolar disorder for many years until he found a nutritional solution for bipolar disorder and he is here today to share his story and inspire others who may be stuck in the spin cycle of pharmaceutical drugs.
Websites:
http://www.thelithiumdoctor.com
http://opsetthemfree.com
http://stopsoldiersuicide.org
DVD: The Hidden Enemy: A Documentary Inside Psychiatry's Covert Agenda by CCHR
You can purchase Lithium Orotate online or by calling ThePowerMall.com at 877-817-9829
and in this case,
lithium orotate just may be one of those things!
DR. MARK MILLAR shares what this natural, organic mineral does for our bodies and how it makes life better by just giving our body this supplement. Dr. Millar is a retired Chiropractor who has spent the last 3 years writing two books on the topic of a nutritional breakthrough for PTSD, Depression, Traumatic Brain Injury, suicide and Alzheimer's disease.
Dr. Millar was called to this mission by his personal experience suffering with bipolar disorder for many years until he found a nutritional solution for bipolar disorder and he is here today to share his story and inspire others who may be stuck in the spin cycle of pharmaceutical drugs.
Websites:
http://www.thelithiumdoctor.com
http://opsetthemfree.com
http://stopsoldiersuicide.org
DVD: The Hidden Enemy: A Documentary Inside Psychiatry's Covert Agenda by CCHR
You can purchase Lithium Orotate online or by calling ThePowerMall.com at 877-817-9829
_______________________________________________________________________________
_______________________________________________________________________________
IS LITHIUM OROTATE GOOD OR BAD FOR YOU?
by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
The health benefits of lithium orotate are causing an explosion in its popularity. I’ve been an advocate of lithium orotate for quite some time and have incorporated into some of my own formulations. A friend of mine, Dr. Mark Millar, is the leading authority on lithium orotate in the United States today. He published an eBook, “Veteran Suicide Breakthrough: Revealing the Breakthrough Mineral for Suicide Prevention, PTSD and Depression ‘They Definitely’ Don’t Want You to Know About” which is loaded with facts on lithium’s effects on the both body and brain.
I’d really encourage you to check out his book, it’s powerful information you’re not going to hear from any mainstream source. I’d like to share a few of the shocking facts contained within the pages of Dr. Millar’s book but must reiterate that much of this is very controversial, disputed by the mainstream medical establishment, and should not be interpreted as claims, promises, or fodder to diagnose yourself. I am sharing this for educational purposes only!
• “Technically, lithium is not a drug but a mineral, similar to salt.” -VA Research Currents
• “In fact, lithium isn’t a drug at all. It’s actually a mineral-part of the same family of minerals that includes sodium and potassium.” -Jonathan Wright, M.D., author of “The Importance of Lithium Supplementation”
• Medical doctors are now speaking out about the essential trace mineral known as lithium, promoting its incredible therapeutic benefits at low doses.
• “Shocking but true — lithium is an essential trace element.” -Emily Deans, M.D., (Harvard trained psychiatrist) author of “Could You Have a Lithium Deficiency?”
• “Lithium is an essential micronutrient… It is present in all organs and tissues in the body. It has similar chemical properties to that of calcium and magnesium.” -Mark Hyman, M.D., best-selling author of “The UltraMind Solution”
• “Lithium is one of the most important elements in the human body.” -Lawrence Wilson, M.D., author of “Lithium”
• In animal studies, lithium has been shown to be an essential trace mineral. When lithium is removed from the diet of farm animals, they appear to develop numerous chronic, degenerative diseases. These include atrophy of the spleen, development of cysts and tumors, severely depressed immune systems, and decreased fertility. Additionally, the quantity of breast milk is diminished in nursing mothers with inadequate lithium stores.
• A study from Texas analyzed 27 state counties between the years of 1978-1987. It was discovered that the incidence of suicide, homicide, rape, drug abuse, and felonious acts were about 50% lower in the 27 counties with lithium-containing drinking water. The water had lithium levels ranging from 70-170 micrograms/L. Additionally, the study found a significant reduction in drug-related arrests within the same time period and locations.
• Lithium orotate “…does not require blood tests to establish a therapeutic level as prescription forms do, nor is it toxic to the kidneys like lithium pharmaceuticals.” In addition, “…Prescription lithium is poorly absorbed by cells, the main site where it performs its functions.” -Ward Dean, M.D.
• Medical doctors have found doses of lithium orotate 80-90% lower than the orthodox Pharma-lithium dosage for major depressive disorder, also known as clinical depression, unipolar depression, major depression, or unipolar disorder. 50-70% of patients have shown fair to good response with lithium use for depression.
• According to Jonathan Wright, M.D., America’s top authority on lithium orotate, a total daily intake of 30 milligrams of elemental lithium will have unnoticeable effects on serum lithium levels, with levels usually residing in a non-detectable range. Even 40 mg per day appears to be completely safe, presenting no negative side effects or signs of toxicity.
• Dr. Write also testifies that, “After decades of clinical research and laboratory testing of the compound on my patients, I discovered that administering lithium orotate up to 40 mg per day to be completely safe (without negative side effects or toxicity) and absolutely effective in the control of numerous mental, neurological, and physical conditions.”
• Another form of lithium, called lithium orotate, is preferred because the orotate ion crosses the blood-brain barrier more easily than the carbonate ion of the pharmaceutical lithium carbonate. Therefore, lithium orotate can be used in much lower servings (e.g. 5 mg) with remarkable results and no side effects. -Shaheen Lakhan, M.D., author of “Nutritional Therapies for Mental Disorders”
• “Lithium itself is not a drug; it’s a naturally occurring mineral salt like potassium, and is something you need for proper mental and physical health… Lithium orotate may be a safe and simple way to help beat the blues.” -Al Sears, M.D.
• “The lithium salt of orotic acid (lithium orotate) improves the effects of lithium several-fold by increasing lithium bio-utilization.” -Ward Dean, M.D., author of “The Unique Safe Mineral with Multiple Uses”
• Dr. Dean also states, “Lithium orotate has also been successfully used in alleviating discomfort from migraine and cluster headaches, improving low white blood cell counts, juvenile convulsive disease, alcoholism, and liver disorders. Lithium Orotate is extremely safe, with no known adverse side effects or drug interactions.”
• “Prescription lithium is poorly absorbed by the cells, where it needs to be to do its job… Because it is so poorly absorbed, blood levels need to be fairly high to “drive” it into the cells. Unfortunately, these “therapeutic” blood levels are dangerously close to the toxic level. That’s why patients on prescription lithium need to be carefully monitored… Successful dosing with lithium orotate is measured by clinical effects on the patient, rather than by blood levels.” -Ward Dean, M.D.
• “Lithium Orotate will not cause weight gain, nor will it cause sedation or sleepiness.” -Ward Dean, M.D.
• In one study, 42 patients hospitalized for the management of their alcoholism were given 150 mg of lithium orotate every day. It was found that lithium orotate helped improve the effectiveness of alcoholism treatment. Ten of the patients experienced no relapse for over three to ten years. 13 patients remained alcohol-free for one to two years, and the remaining 12 experienced a relapse between 6 to 12 months. Lithium orotate therapy was seen as relatively safe, with minor adverse side effects seen in some patients (muscle weakness, appetite loss, mild apathy). For these patients, symptoms subsided following the reduction of lithium orotate administration.
Over 50% of the alcoholic patients who completed this study were without relapse for over one year and 25% of them made it over 3 years without a relapse. NOTE: The discovery of decreasing mild side effects through slightly reducing lithium orotate supplementation provides further scientific evidence that lithium has no inherent toxicity when taken in smaller, reasonable dosages. -A study titled: “Lithium orotate in the treatment of alcoholism and related conditions.”
• Available without a prescription, lithium orotate has been marketed as an alternative to the prescription known as lithium carbonate. In lithium orotate, lithium is joined with an orotate ion, rather than to a carbonate ion.
• “Lithium orotate is a highly bioavailable form of lithium that is available as an over-the-counter dietary supplement.” -Linda Fugate, Ph.D., author of “Lithium’s Potential Role in Preventing Alzheimer’s Disease”
• “In small servings (15 mg/day), lithium orotate has been shown to protect the central nervous system.” -Dietrich K. Klinghardt, M.D, Ph.D.
• “Lithium is a trace element which has important functions in the brain, including protecting brain cells from various toxins and reducing the ill effects of certain excitatory neurotransmitters which are harmful in large amounts.” -Alice R. Laule, M.D., author of “Lithium”
• “Lithium orotate, on the other hand, is more bioavailable and safer than the lithium carbonate.” -Jeffrey Dach, M.D., author of “Beating Depression Naturally”
• “Lithium is one of the most important elements in the human body.” -Lawrence Wilson, M.D., author of “Lithium”
• Harvard Medical School has analyzed over 30 human meta-analysis studies and has determined that lithium reduces the rate and risk of suicide attempts by 80-90% in patients with major depression, bipolar disorder, and schizoaffective disorder. In fact, the overall risk of suicides was five times less among lithium-treated subjects compared with individuals not treated with lithium.
• In human studies among healthy populations, lithium has been shown to significantly increase brain mass in both gray and white matter.
• Lithium is the most powerful essential trace mineral ever discovered for promoting optimal functioning of the brain and central nervous system.
• Lithium augmentation appears to be a promising therapy for geriatric depressed patients who are unresponsive to, or cannot tolerate, other standard therapies.
• “In some cases, adjunctive lithium leads to improvement in depressive symptoms very quickly, usually in 2 or 3 days.”
• In a placebo-controlled human study, lithium reduced histamine and bronchial reactivity in airway smooth muscle, improving symptom scores and significantly reducing the need of inhalers. Lithium also significantly reduced the contractile effect of histamine on the tissues of the lung and trachea in guinea pigs.
• Lithium may prevent calcification of blood vessels in humans. Animals rendered lithium deficient in lab testing developed calcification of blood vessels, increasing the risk for heart disease.
• Lithium has been shown to reduce excessive levels of arachidonic acid in the brains of rats. “…lithium might be considered for treating human brain diseases accompanied by neuroinflammation.”
• A comprehensive review of contemporary research conducted in 2010 and published in the Harvard Review of Psychiatry, determined that lithium is still the gold standard for the treatment of bipolar disorder.
• Lithium has been discovered to produce profound improvement of immune function by increasing these white blood cell components: granulocytes, monocytes, natural killer T-cells, and immunoglobulins.
• Multiple studies have suggested lithium’s possible role in preventing and alleviating migraines. In a study involving cyclical migraines, nineteen out of 22 patients (85%) responded to treatment and showed significant improvement in the frequency and severity of migraine headaches. 25% of the patients had complete remission of their migraine headaches and the remaining had a 50-75% reduction. In cluster headaches (the most severe type of headache), lithium is mentioned repeatedly in the research to be effective as a preventative measure.
• Lithium also provides robust protection from heavy metal toxicity. Lithium has been shown to protect cells from aluminum, arsenic, cadmium, lead, and mercury toxicity. Animal studies has positioned lithium as having a protective effect against toxic metals.
• Lithium has profound antiviral properties against herpes infections and may significantly reduce the frequency and severity of herpes outbreaks. “Overall, lithium treatment resulted in a consistent reduction in the mean number of episodes per month, the average duration of each episode, the total number of infection days per month, and the maximum severity of symptoms.”
• Lithium has anti-inflammatory effects upon the bowel. Lithium has demonstrated benefit to ulcerative colitis in humans. Lithium has been shown to decrease symptoms of IBD in children. Lithium works at the core of stress-related illnesses by balancing, normalizing, and regulating stress hormones like adrenaline and noradrenaline. “Lithium, a widely-used drug in bipolar disorders, plays a gastro-protective role. The effects of lithium on several tissues are mediated through nitric oxide…”
• “One substance that I have found to be surprisingly effective for shingles is lithium orotate. Three to four capsules per day have been reported to dramatically reduce disabling pains. Lithium orotate seems to greatly reduce the pain and itching of post-herpetic neuralgia which can linger for months and years after the lesions of shingles have resolved.”
• In 1973, Dr. Hans Nieper reported that approximately 90% of his migraine patients reported significant relief in the frequency and severity of their headaches. He states that he was able to produce these results by utilizing a unique mineral transporter known as orotic acid (aka, orotate), thus allowing him to administer only minute amounts of lithium to achieve maximum results.
• “Lithium orotate contains unparalleled efficiency in the treatment of constitutional migraine, constant headache, and hemicranias, as well as in the treatment of depression, alcoholism and epilepsy… Lithium orotate is effective at uncommonly low dosages and causes no negative side effects.” -Dr. Hans Nieper
• Studies of lithium’s effect upon hyperthyroid conditions consistently demonstrate major regulation of thyroid hormones triiodothyronine (T3) and thyroxine (T4). The most common cause of hyperthyroid hormones is Grave’s disease. In a study of lithium’s effect upon Grave’s disease, it was determined that lithium reduced T3 by 42% and T4 by 28%. These amazing changes occurred in just 7 days.
• “Lithium has been reported to be beneficial in animal models of brain injury, stroke, Alzheimer’s, Huntington’s, and Parkinson’s diseases, Amyotrophic Lateral Sclerosis (ALS), spinal cord injury, and other conditions. A recent clinical trial suggests that lithium stops the progression of ALS. The stimulation of endogenous neural stem cells may explain why lithium increases brain cell density and volume in patients with bipolar disorders.”
• The majority of OCD patients are significantly helped by serotonin re-uptake inhibitors (SRIs). “In open-label reports, the addition of… lithium… has yielded encouraging results.”
_______________________________________________________________________________
- 300 mg of Lithium carbonate contains ~ 60 mg of elemental lithium
- 1 – 2 capsules TIB (3 times per day)
- Equals 180 – 360 mg of elemental lithium
- 100 mg of lithium orotate contains ~ 5 mg of elemental lithium
- 1 – 2 tablets TIB
- Equals 15 – 30 mg of elemental lithium
If someone takes 1200 mg. Lithium Carbonate daily.
Than the person needs 240 mg of elemental lithium.
If each capsule contains 5 mg ... he would need 48 capsules... that is alot of capsules ... you might need to look around at other capsules that contain more.. or even look into making your own.. you might be able to get real large capsules and cut the dose in half...
Than the person needs 240 mg of elemental lithium.
If each capsule contains 5 mg ... he would need 48 capsules... that is alot of capsules ... you might need to look around at other capsules that contain more.. or even look into making your own.. you might be able to get real large capsules and cut the dose in half...
Related Articles:
Dr. Michelle Kmiec
is a chiropractor who also holds a Bachelor of Science degree in Human Biology. She is life-long athlete who after curing herself 100% naturally from MS and anxiety became an avid nutrition health researcher/promoter. She has been featured in many Health magazines, and has been a guest on radio talk shows in the USA, Canada, United Kingdom, and Australia.
She is the author of Healthcare Freedom Revolution: Exposing the Lies, Deceit and Greed of the Medical Profession, Founder of Online Holistic Health Website/Blog and its exclusive holistic community, The Triad of Life, and a contributing writer for several popular informative health website/blogs.
- See more at: http://www.onlineholistichealth.com/lithium-orotate-misleading-research/#sthash.uZtoMnM8.dpuf
- Lithium – The Misunderstood Mineral Part 1
- Lithium – The Misunderstood Mineral Part 2
- Potential Role for Lithium in Preventing Alzheimer’s Disease
- The Safe, Unique Mineral with Multiple Uses
Dr. Michelle Kmiec
is a chiropractor who also holds a Bachelor of Science degree in Human Biology. She is life-long athlete who after curing herself 100% naturally from MS and anxiety became an avid nutrition health researcher/promoter. She has been featured in many Health magazines, and has been a guest on radio talk shows in the USA, Canada, United Kingdom, and Australia.
She is the author of Healthcare Freedom Revolution: Exposing the Lies, Deceit and Greed of the Medical Profession, Founder of Online Holistic Health Website/Blog and its exclusive holistic community, The Triad of Life, and a contributing writer for several popular informative health website/blogs.
- See more at: http://www.onlineholistichealth.com/lithium-orotate-misleading-research/#sthash.uZtoMnM8.dpuf
http://www.onlineholistichealth.com/lithium-orotate-misleading-research/
The Safe Mineral
Dr. Michelle Kmiec
Lithium Orotate The Safe, Unique Mineral with Multiple Uses
by Ward Dean, M.D. and Jim English
Lithium is a mineral with a cloudy reputation. It is an alkali metal in the same family as sodium, potassium and other elements. Although lithium is highly effective in the treatment of manic depressive illness (X4 DI), its pharmaceutical (prescription) versions, lithium carbonate and lithium citrate, must be used with caution.
The reason for the caution with prescription lithium is because lithium in these forms is poorly absorbed by the cells of the body — and it is within the cells that lithium’s therapeutic effects take place. Lithium ions are believed to act only at particular sites on the membranes of intracellular structures like mitochondria and lysosomes.
Consequently, because of this poor intracellular transport, high dosages of pharmaceutical forms of lithium must be taken in order to obtain a satisfactory therapeutic effect. Unfortunately, these therapeutic dosages cause blood levels to be so high that they border on toxic levels. Consequently, patients taking prescription lithium must be closely monitored for toxic blood levels. Serum lithium and serum creatinine levels of prescription lithium-treated patients should be monitored every 3-6 months.
Toxic effects of lithium may include hand tremors, frequent urination, thirst, nausea, and vomiting. Even higher doses may cause drowsiness, muscular weakness, poor coordination, ringing in the ears, blurred vision, and other symptoms.
There has been concern that long-term lithium treatment may damage kidney function, but data in this regard are equivocal. Renal insufficiency without a known cause has occurred in the general population, and the incidence of renal failure among manic-depressive patients not treated with lithium remains unknown.
Most patients treated with lithium are also taking other medications, and it is just as likely that the few known cases of renal failure in patients taking lithium were due to other medications that they were simultaneously taking. 2-5
Nevertheless, with potential side effects like this, why in the world would anyone want to take lithium? It is because lithium has been found to be one of the most effective treatments for manic-depressive illness (bi-polar disorder).
Bipolar Disorder
Bipolar disorder is a severe mood disorder characterized by manic or depressive episodes that usually cycle back and forth between depression and mania. The depressive phase is characterized by sluggishness (inertia), loss of self-esteem, helplessness, withdrawal and sadness, with suicide being a risk. The manic phase is characterized by elation, hyperactivity, over-involvement in activities, inflated self-esteem, a tendency to be easily distracted, and little need for sleep. In either phase there is frequently a dependence on alcohol or other substances of abuse.
The disorder first appears between the ages of 15 and 25 and affects men and women equally. The cause is unknown, but hereditary and psychological factors may play a role. The incidence is higher in relatives of people with bipolar disorders. A psychiatric history of mood swings, and an observation of current behavior and mood are important in the diagnosis of this disorder.7
Orthodox Treatment
Hospitalization may be required during an acute phase to control the symptoms. Antidepressant drugs may be given; anticonvulsants (Carbamazepine, Valproic acid, Depakote) may also be used. (These substances deplete body stores of L-carnitine and Taurine. Supplementation with several grams daily of these supplements greatly ameliorates adverse side effects of these drugs).
Lithium, however, is the treatment of choice for recurring bipolar (manic/depressive) illness, serving as an effective mood enhancer in 70-80 percent of bipolar patients.
Mortality-lowering, Anti-suicidal Effect of Lithium
The mortality of manic-depressive patients is markedly higher than that of the general population. The increased mortality is mainly, but not exclusively, caused by suicide. Studies have shown that the mortality of manic-depressive patients given long-term lithium treatment is markedly lower than that of patients not receiving lithium.
The frequency of suicidal acts among treated patients is significantly lower than patients given other antidepressants or carbamazepine. The results of mortality studies are consistent with the assumption that lithium-treatment protects against suicidal behavior. 8-13
Unipolar Disorder
In addition to its well-recognized benefits in the management of bipolar disorder, trials have conclusively demonstrated that lithium is also an effective treatment for recurrent unipolar depressive illness (recurrent major affective disorder).14-16
Although physicians in Europe have successfully used lithium for this indication for many years, American psychiatrists do not share their appreciation of lithium’s safety and effectiveness for conditions other than MDI. Perhaps it is due to a difference in the lithium preparations they have at their disposal.
Superiority of Lithium Orotate
The lithium salt of orotic acid (lithium orotate) improves the specific effects of lithium many-fold by increasing lithium bio-utilization. The orotates transport the lithium to the membranes of mitochondria, lysosomes and the glia cells. Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts. Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium.
For example, in cases of severe depression, the therapeutic dosage of lithium orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse lithium side reactions and no need for monitoring blood serum measurements.17
Other Uses for Lithium Orotate
Lithium orotate has also been used with success in alleviating the pain from migraine and cluster headaches, low white blood counts, juvenile convulsive disease, alcoholism and liver disorders.18 Nieper also reports that patients with myopia (nearsightedness) and glaucoma often benefit from the slight dehydrating effect of lithium on the eye, resulting in improvement in vision and reduction of intraocular pressure.17
References
1. Aronson JK, Reynolds DJM. ABC of monitoring drag therapy: lithium. BMJ. 1992;305: 1273-1276.
2. Schou M, Effects of long-term lithium treatment on kidney function: an overview. J Psychiat Res, 1988;22.,287-296,
3. Waller DG, Edwards TG. Lithium and the kidney: an update. Psycliol Mod. 1989; 19:825-83 1.
4. Gitlin MJ. Lithium-induced renal insufficiency., J Clin Psychopharmacol. 1993) 13:276-279.
5, Kallner G,.Petterson IJ. Renal, thyroid and parathyroid function during lithium treatment: laboratory test in 207 people treated for 1-30 years. Acta Psychiatr Scand. 1995;91:48-5 1.
6. Baastrup PC, Schou M. Lithium as a prophylactic agent: its effect against recurrent depressions and manic-depressive psychosis. Arch Gen Psychiatry. 1967; 16:162-172.
7. Goodwin FK, Jamison KR. Manic-Depressive Illness. Oxford, England: Oxford University Press; 1990.
8. Mueller-Oerlinghausen D, Ahrens B, Volk J, Grof P, Grof E, Schou M, Vestergaard P, Lenz G, Sinihandl C, Tlau K, Wolf R. Reduced mortality of manic-depressive patients in long-term lithium treatment, an international collaborative study by IGSLI. Psychiatry Res. 1991;36:329-331.
9. Ahrens B, Mueller-Oerlinghausen 3, Schou M, Wolf T, Alda M, Grof. E. Grof P, Lejiz G, Simhandl C, Thau K, Vestergaard P, Wolf R, Moeller H. Cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis. J Affect DI-Y, 1995;33:67-75.
10. Mueller-Oerlinghausen B, Mueser-Causemam B, Volk J. Suicides and parasuicides in a high-risk patient group on and off lithium long-term medication, J Affect Dis. 1992;25: 261-270.
11. Felber- NV, Kyber A. Suizide und Parasuizide wachrend und aubetadserhalb einer Lithiumprophylaxe. In-, Muclicr-Oerlinghausen B, Berghoefer A, eds. Ziele und Ergebnisse der medikagivitoeseyi I-i-opiiylaice affektiver Psychoseii. Stuttgart, Germany, Thieme; 1994:53-59.
12. Thies-Flechtner K, Seibert W, Walther A, Greil W, Mueller-Oerlinghausen B, Suizide bei rezldlvprophylaktisch behandelten Patienten mit affektiven Psychosen. In: Mueller-Oerlinghausen B, Berghoefer A, eds. Ziele und Ergebnisse der medikamentoesen Prophylaxe offekliver Psychosen. Stuttgart, Germany. Thieme; 1994,61-64.
13. Schou M.. Mortality-lowering effect of prophylactic lithium treatment, a look at the evidence, Pharmacopsychiatry. 1995;28: 1.
14. Souza FGM, Goodwin GM. Lithium treatment and prophylaxis in unipolar depression: a meta-analysis, Br J Psychiatry. 1991; 158:666-675.
15. Johnstone EC, Owens DGC, Lambert MT, Crow TJ, Frith CD, Done DJ. Combination tricyclic, antidepressant and lithium maintenance medication in unipolar and bipolar depressed patients. J Affect Dis, 1990;20:225-233,
16. Prien RF, Kupfer DJ, Mansky PA, Small JG, ‘I’uason VB, Voss CB, Johnson WE. Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Arch Gen Psychiatry, 1984;41.1096-1104,
17. Nieper HA The clinical application of lithium orotate. Agressologie 14(6). 407-411, 1973,
18. Sartori HE, Lithium orotate in the treatment of alcoholism and related conditions, Alcohol 1986 Mar; 3 (2): 97-100.
19. Nieper HA The curative effect of a combination of Calcium-orotate and Lithium orotate on primary and secondary chronic hepatitis and primary and secondary liver cirrhosis. From lecture Intl Acad of Prevent Med, Washington, DC March 9, 1974.
(The information in this article is not intended to provide personal medical advice, which should be obtained from a medical professional.)
- See more at: http://www.onlineholistichealth.com/safe-mineral/#sthash.fymyHYFi.dpuf
The Safe Mineral
Dr. Michelle Kmiec
Lithium Orotate The Safe, Unique Mineral with Multiple Uses
by Ward Dean, M.D. and Jim English
Lithium is a mineral with a cloudy reputation. It is an alkali metal in the same family as sodium, potassium and other elements. Although lithium is highly effective in the treatment of manic depressive illness (X4 DI), its pharmaceutical (prescription) versions, lithium carbonate and lithium citrate, must be used with caution.
The reason for the caution with prescription lithium is because lithium in these forms is poorly absorbed by the cells of the body — and it is within the cells that lithium’s therapeutic effects take place. Lithium ions are believed to act only at particular sites on the membranes of intracellular structures like mitochondria and lysosomes.
Consequently, because of this poor intracellular transport, high dosages of pharmaceutical forms of lithium must be taken in order to obtain a satisfactory therapeutic effect. Unfortunately, these therapeutic dosages cause blood levels to be so high that they border on toxic levels. Consequently, patients taking prescription lithium must be closely monitored for toxic blood levels. Serum lithium and serum creatinine levels of prescription lithium-treated patients should be monitored every 3-6 months.
Toxic effects of lithium may include hand tremors, frequent urination, thirst, nausea, and vomiting. Even higher doses may cause drowsiness, muscular weakness, poor coordination, ringing in the ears, blurred vision, and other symptoms.
There has been concern that long-term lithium treatment may damage kidney function, but data in this regard are equivocal. Renal insufficiency without a known cause has occurred in the general population, and the incidence of renal failure among manic-depressive patients not treated with lithium remains unknown.
Most patients treated with lithium are also taking other medications, and it is just as likely that the few known cases of renal failure in patients taking lithium were due to other medications that they were simultaneously taking. 2-5
Nevertheless, with potential side effects like this, why in the world would anyone want to take lithium? It is because lithium has been found to be one of the most effective treatments for manic-depressive illness (bi-polar disorder).
Bipolar Disorder
Bipolar disorder is a severe mood disorder characterized by manic or depressive episodes that usually cycle back and forth between depression and mania. The depressive phase is characterized by sluggishness (inertia), loss of self-esteem, helplessness, withdrawal and sadness, with suicide being a risk. The manic phase is characterized by elation, hyperactivity, over-involvement in activities, inflated self-esteem, a tendency to be easily distracted, and little need for sleep. In either phase there is frequently a dependence on alcohol or other substances of abuse.
The disorder first appears between the ages of 15 and 25 and affects men and women equally. The cause is unknown, but hereditary and psychological factors may play a role. The incidence is higher in relatives of people with bipolar disorders. A psychiatric history of mood swings, and an observation of current behavior and mood are important in the diagnosis of this disorder.7
Orthodox Treatment
Hospitalization may be required during an acute phase to control the symptoms. Antidepressant drugs may be given; anticonvulsants (Carbamazepine, Valproic acid, Depakote) may also be used. (These substances deplete body stores of L-carnitine and Taurine. Supplementation with several grams daily of these supplements greatly ameliorates adverse side effects of these drugs).
Lithium, however, is the treatment of choice for recurring bipolar (manic/depressive) illness, serving as an effective mood enhancer in 70-80 percent of bipolar patients.
Mortality-lowering, Anti-suicidal Effect of Lithium
The mortality of manic-depressive patients is markedly higher than that of the general population. The increased mortality is mainly, but not exclusively, caused by suicide. Studies have shown that the mortality of manic-depressive patients given long-term lithium treatment is markedly lower than that of patients not receiving lithium.
The frequency of suicidal acts among treated patients is significantly lower than patients given other antidepressants or carbamazepine. The results of mortality studies are consistent with the assumption that lithium-treatment protects against suicidal behavior. 8-13
Unipolar Disorder
In addition to its well-recognized benefits in the management of bipolar disorder, trials have conclusively demonstrated that lithium is also an effective treatment for recurrent unipolar depressive illness (recurrent major affective disorder).14-16
Although physicians in Europe have successfully used lithium for this indication for many years, American psychiatrists do not share their appreciation of lithium’s safety and effectiveness for conditions other than MDI. Perhaps it is due to a difference in the lithium preparations they have at their disposal.
Superiority of Lithium Orotate
The lithium salt of orotic acid (lithium orotate) improves the specific effects of lithium many-fold by increasing lithium bio-utilization. The orotates transport the lithium to the membranes of mitochondria, lysosomes and the glia cells. Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts. Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium.
For example, in cases of severe depression, the therapeutic dosage of lithium orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse lithium side reactions and no need for monitoring blood serum measurements.17
Other Uses for Lithium Orotate
Lithium orotate has also been used with success in alleviating the pain from migraine and cluster headaches, low white blood counts, juvenile convulsive disease, alcoholism and liver disorders.18 Nieper also reports that patients with myopia (nearsightedness) and glaucoma often benefit from the slight dehydrating effect of lithium on the eye, resulting in improvement in vision and reduction of intraocular pressure.17
References
1. Aronson JK, Reynolds DJM. ABC of monitoring drag therapy: lithium. BMJ. 1992;305: 1273-1276.
2. Schou M, Effects of long-term lithium treatment on kidney function: an overview. J Psychiat Res, 1988;22.,287-296,
3. Waller DG, Edwards TG. Lithium and the kidney: an update. Psycliol Mod. 1989; 19:825-83 1.
4. Gitlin MJ. Lithium-induced renal insufficiency., J Clin Psychopharmacol. 1993) 13:276-279.
5, Kallner G,.Petterson IJ. Renal, thyroid and parathyroid function during lithium treatment: laboratory test in 207 people treated for 1-30 years. Acta Psychiatr Scand. 1995;91:48-5 1.
6. Baastrup PC, Schou M. Lithium as a prophylactic agent: its effect against recurrent depressions and manic-depressive psychosis. Arch Gen Psychiatry. 1967; 16:162-172.
7. Goodwin FK, Jamison KR. Manic-Depressive Illness. Oxford, England: Oxford University Press; 1990.
8. Mueller-Oerlinghausen D, Ahrens B, Volk J, Grof P, Grof E, Schou M, Vestergaard P, Lenz G, Sinihandl C, Tlau K, Wolf R. Reduced mortality of manic-depressive patients in long-term lithium treatment, an international collaborative study by IGSLI. Psychiatry Res. 1991;36:329-331.
9. Ahrens B, Mueller-Oerlinghausen 3, Schou M, Wolf T, Alda M, Grof. E. Grof P, Lejiz G, Simhandl C, Thau K, Vestergaard P, Wolf R, Moeller H. Cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis. J Affect DI-Y, 1995;33:67-75.
10. Mueller-Oerlinghausen B, Mueser-Causemam B, Volk J. Suicides and parasuicides in a high-risk patient group on and off lithium long-term medication, J Affect Dis. 1992;25: 261-270.
11. Felber- NV, Kyber A. Suizide und Parasuizide wachrend und aubetadserhalb einer Lithiumprophylaxe. In-, Muclicr-Oerlinghausen B, Berghoefer A, eds. Ziele und Ergebnisse der medikagivitoeseyi I-i-opiiylaice affektiver Psychoseii. Stuttgart, Germany, Thieme; 1994:53-59.
12. Thies-Flechtner K, Seibert W, Walther A, Greil W, Mueller-Oerlinghausen B, Suizide bei rezldlvprophylaktisch behandelten Patienten mit affektiven Psychosen. In: Mueller-Oerlinghausen B, Berghoefer A, eds. Ziele und Ergebnisse der medikamentoesen Prophylaxe offekliver Psychosen. Stuttgart, Germany. Thieme; 1994,61-64.
13. Schou M.. Mortality-lowering effect of prophylactic lithium treatment, a look at the evidence, Pharmacopsychiatry. 1995;28: 1.
14. Souza FGM, Goodwin GM. Lithium treatment and prophylaxis in unipolar depression: a meta-analysis, Br J Psychiatry. 1991; 158:666-675.
15. Johnstone EC, Owens DGC, Lambert MT, Crow TJ, Frith CD, Done DJ. Combination tricyclic, antidepressant and lithium maintenance medication in unipolar and bipolar depressed patients. J Affect Dis, 1990;20:225-233,
16. Prien RF, Kupfer DJ, Mansky PA, Small JG, ‘I’uason VB, Voss CB, Johnson WE. Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Arch Gen Psychiatry, 1984;41.1096-1104,
17. Nieper HA The clinical application of lithium orotate. Agressologie 14(6). 407-411, 1973,
18. Sartori HE, Lithium orotate in the treatment of alcoholism and related conditions, Alcohol 1986 Mar; 3 (2): 97-100.
19. Nieper HA The curative effect of a combination of Calcium-orotate and Lithium orotate on primary and secondary chronic hepatitis and primary and secondary liver cirrhosis. From lecture Intl Acad of Prevent Med, Washington, DC March 9, 1974.
(The information in this article is not intended to provide personal medical advice, which should be obtained from a medical professional.)
- See more at: http://www.onlineholistichealth.com/safe-mineral/#sthash.fymyHYFi.dpuf
Is Lithium Orotate Good or Bad for You?
by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
http://www.globalhealingcenter.com/natural-health/is-lithium-orotate-good-or-bad-for-you/
Email
The health benefits of lithium orotate are causing an explosion in its popularity. I’ve been an advocate of lithium orotate for quite some time and have incorporated into some of my own formulations.
A friend of mine, Dr. Mark Millar, is the leading authority on lithium orotate in the United States today. He published an eBook, “Veteran Suicide Breakthrough: Revealing the Breakthrough Mineral for Suicide Prevention, PTSD and Depression ‘They Definitely’ Don’t Want You to Know About” which is loaded with facts on lithium’s effects on the both body and brain.
I’d really encourage you to check out his book, it’s powerful information you’re not going to hear from any mainstream source. I’d like to share a few of the shocking facts contained within the pages of Dr. Millar’s book but must reiterate that much of this is very controversial, disputed by the mainstream medical establishment, and should not be interpreted as claims, promises, or fodder to diagnose yourself.
I am sharing this for informational purposes only! Lithium orotate is intended as a nutrient to supplement the diet. Its effects are nutritional. The statements in this article have not been evaluated by the Food and Drug Administration and this nutrient is not intended to diagnose, treat, cure or prevent any disease.
by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM
http://www.globalhealingcenter.com/natural-health/is-lithium-orotate-good-or-bad-for-you/
The health benefits of lithium orotate are causing an explosion in its popularity. I’ve been an advocate of lithium orotate for quite some time and have incorporated into some of my own formulations.
A friend of mine, Dr. Mark Millar, is the leading authority on lithium orotate in the United States today. He published an eBook, “Veteran Suicide Breakthrough: Revealing the Breakthrough Mineral for Suicide Prevention, PTSD and Depression ‘They Definitely’ Don’t Want You to Know About” which is loaded with facts on lithium’s effects on the both body and brain.
I’d really encourage you to check out his book, it’s powerful information you’re not going to hear from any mainstream source. I’d like to share a few of the shocking facts contained within the pages of Dr. Millar’s book but must reiterate that much of this is very controversial, disputed by the mainstream medical establishment, and should not be interpreted as claims, promises, or fodder to diagnose yourself.
I am sharing this for informational purposes only! Lithium orotate is intended as a nutrient to supplement the diet. Its effects are nutritional. The statements in this article have not been evaluated by the Food and Drug Administration and this nutrient is not intended to diagnose, treat, cure or prevent any disease.
- “Technically, lithium is not a drug but a mineral, similar to salt.” -VA Research Currents
- “In fact, lithium isn’t a drug at all. It’s actually a mineral-part of the same family of minerals that includes sodium and potassium.” -Jonathan Wright, M.D., author of “The Importance of Lithium Supplementation”
- Medical doctors are now speaking out about the essential trace mineral known as lithium, promoting its incredible therapeutic benefits at low servings.
- “Shocking but true — lithium is an essential trace element.” -Emily Deans, M.D., (Harvard trained psychiatrist) author of “Could You Have a Lithium Deficiency?”
- “Lithium is an essential micronutrient… It is present in all organs and tissues in the body. It has similar chemical properties to that of calcium and magnesium.” -Mark Hyman, M.D., best-selling author of “The UltraMind Solution”
- “Lithium is one of the most important elements in the human body.” -Lawrence Wilson, M.D., author of “Lithium”
- In animal studies, lithium has been shown to be an essential trace mineral. When lithium is removed from the diet of farm animals, they appear to develop numerous chronic, degenerative diseases. These include atrophy of the spleen, development of cysts and tumors, severely depressed immune systems, and decreased fertility. Additionally, the quantity of breast milk is diminished in nursing mothers with inadequate lithium stores.
- A study from Texas analyzed 27 state counties between the years of 1978-1987. It was discovered that the incidence of suicide, homicide, rape, drug abuse, and felonious acts were about 50% lower in the 27 counties with lithium-containing drinking water. The water had lithium levels ranging from 70-170 micrograms/L. Additionally, the study found a significant reduction in drug-related arrests within the same time period and locations.
- Lithium orotate “…does not require blood tests to establish a therapeutic level as prescription forms do, nor is it toxic to the kidneys like lithium pharmaceuticals.” In addition, “…Prescription lithium is poorly absorbed by cells, the main site where it performs its functions.” -Ward Dean, M.D.
- Medical doctors have found servings of lithium orotate 80-90% lower than the orthodox Pharma-lithium serving for major depressive disorder, also known as clinical depression, unipolar depression, major depression, or unipolar disorder. 50-70% of patients have shown fair to good response with lithium use for depression.
- According to Jonathan Wright, M.D., America’s top authority on lithium orotate, a total daily intake of 30 milligrams of elemental lithium will have unnoticeable effects on serum lithium levels, with levels usually residing in a non-detectable range. Even 40 mg per day appears to be completely safe, presenting no negative side effects or signs of toxicity.
- Dr. Wright also testifies that, “After decades of clinical research and laboratory testing of the compound on my patients, I discovered that administering lithium orotate up to 40 mg per day to be completely safe (without negative side effects or toxicity) and absolutely effective in the control of numerous mental, neurological, and physical conditions.”
- Another form of lithium, called lithium orotate, is preferred because the orotate ion crosses the blood-brain barrier more easily than the carbonate ion of the pharmaceutical lithium carbonate. Therefore, lithium orotate can be used in much lower servings (e.g. 5 mg) with remarkable results and no side effects. -Shaheen Lakhan, M.D., author of “Nutritional Therapies for Mental Disorders”
- “Lithium itself is not a drug; it’s a naturally occurring mineral salt like potassium, and is something you need for proper mental and physical health… Lithium orotate may be a safe and simple way to help beat the blues.” -Al Sears, M.D.
- “The lithium salt of orotic acid (lithium orotate) improves the effects of lithium several-fold by increasing lithium bio-utilization.” -Ward Dean, M.D., author of “The Unique Safe Mineral with Multiple Uses”
- Dr. Dean also states, “Lithium orotate has also been successfully used in alleviating discomfort from migraine and cluster headaches, improving low white blood cell counts, juvenile convulsive disease, alcoholism, and liver disorders. Lithium Orotate is extremely safe, with no known adverse side effects or drug interactions.”
- “Prescription lithium is poorly absorbed by the cells, where it needs to be to do its job… Because it is so poorly absorbed, blood levels need to be fairly high to “drive” it into the cells. Unfortunately, these “therapeutic” blood levels are dangerously close to the toxic level. That’s why patients on prescription lithium need to be carefully monitored… Successful serving with lithium orotate is measured by clinical effects on the patient, rather than by blood levels.” -Ward Dean, M.D.
- “Lithium Orotate will not cause weight gain, nor will it cause sedation or sleepiness.” -Ward Dean, M.D.
- In one study, 42 patients hospitalized for the management of their alcoholism were given 150 mg of lithium orotate every day. It was found that lithium orotate helped improve the effectiveness of alcoholism treatment. Ten of the patients experienced no relapse for over three to ten years. 13 patients remained alcohol-free for one to two years, and the remaining 12 experienced a relapse between 6 to 12 months. Lithium orotate therapy was seen as relatively safe, with minor adverse side effects seen in some patients (muscle weakness, appetite loss, mild apathy). For these patients, symptoms subsided following the reduction of lithium orotate administration.
Over 50% of the alcoholic patients who completed this study were without relapse for over one year and 25% of them made it over 3 years without a relapse. NOTE: The discovery of decreasing mild side effects through slightly reducing lithium orotate supplementation provides further scientific evidence that lithium has no inherent toxicity when taken in smaller, reasonable serving sizes. -A study titled: “Lithium orotate in the treatment of alcoholism and related conditions.” - Available without a prescription, lithium orotate has been marketed as an alternative to the prescription known as lithium carbonate. In lithium orotate, lithium is joined with an orotate ion, rather than to a carbonate ion.
- “Lithium orotate is a highly bioavailable form of lithium that is available as an over-the-counter dietary supplement.” -Linda Fugate, Ph.D., author of “Lithium’s Potential Role in Preventing Alzheimer’s Disease”
- “In small servings (15 mg/day), lithium orotate has been shown to protect the central nervous system.” -Dietrich K. Klinghardt, M.D, Ph.D.
- “Lithium is a trace element which has important functions in the brain, including protecting brain cells from various toxins and reducing the ill effects of certain excitatory neurotransmitters which are harmful in large amounts.” -Alice R. Laule, M.D., author of “Lithium”
- “Lithium orotate, on the other hand, is more bioavailable and safer than the lithium carbonate.” -Jeffrey Dach, M.D., author of “Beating Depression Naturally”
- “Lithium is one of the most important elements in the human body.” -Lawrence Wilson, M.D., author of “Lithium”
- Harvard Medical School has analyzed over 30 human meta-analysis studies and has determined that lithium reduces the rate and risk of suicide attempts by 80-90% in patients with major depression, bipolar disorder, and schizoaffective disorder. In fact, the overall risk of suicides was five times less among lithium-treated subjects compared with individuals not treated with lithium.
- In human studies among healthy populations, lithium has been shown to significantly increase brain mass in both gray and white matter.
- Lithium is the most powerful essential trace mineral ever discovered for promoting optimal functioning of the brain and central nervous system.
- Lithium augmentation appears to be a promising therapy for geriatric depressed patients who are unresponsive to, or cannot tolerate, other standard therapies.
- “In some cases, adjunctive lithium leads to improvement in depressive symptoms very quickly, usually in 2 or 3 days.”
- In a placebo-controlled human study, lithium reduced histamine and bronchial reactivity in airway smooth muscle, improving symptom scores and significantly reducing the need of inhalers. Lithium also significantly reduced the contractile effect of histamine on the tissues of the lung and trachea in guinea pigs.
- Lithium may prevent calcification of blood vessels in humans. Animals rendered lithium deficient in lab testing developed calcification of blood vessels, increasing the risk for heart disease.
- Lithium has been shown to reduce excessive levels of arachidonic acid in the brains of rats. “…lithium might be considered for treating human brain diseases accompanied by neuroinflammation.”
- A comprehensive review of contemporary research conducted in 2010 and published in the Harvard Review of Psychiatry, determined that lithium is still the gold standard for the treatment of bipolar disorder.
- Lithium has been discovered to produce profound improvement of immune function by increasing these white blood cell components: granulocytes, monocytes, natural killer T-cells, and immunoglobulins.
- Multiple studies have suggested lithium’s possible role in preventing and alleviating migraines. In a study involving cyclical migraines, nineteen out of 22 patients (85%) responded to treatment and showed significant improvement in the frequency and severity of migraine headaches. 25% of the patients had complete remission of their migraine headaches and the remaining had a 50-75% reduction. In cluster headaches (the most severe type of headache), lithium is mentioned repeatedly in the research to be effective as a preventative measure.
- Lithium also provides robust protection from heavy metal toxicity. Lithium has been shown to protect cells from aluminum, arsenic, cadmium, lead, and mercury toxicity. Animal studies has positioned lithium as having a protective effect against toxic metals.
- Lithium has profound antiviral properties against herpes infections and may significantly reduce the frequency and severity of herpes outbreaks. “Overall, lithium treatment resulted in a consistent reduction in the mean number of episodes per month, the average duration of each episode, the total number of infection days per month, and the maximum severity of symptoms.”
- Lithium has anti-inflammatory effects upon the bowel. Lithium has demonstrated benefit to ulcerative colitis in humans. Lithium has been shown to decrease symptoms of IBD in children. Lithium works at the core of stress-related illnesses by balancing, normalizing, and regulating stress hormones like adrenaline and noradrenaline. “Lithium, a widely-used drug in bipolar disorders, plays a gastro-protective role. The effects of lithium on several tissues are mediated through nitric oxide…”
- “One substance that I have found to be surprisingly effective for shingles is lithium orotate. Three to four capsules per day have been reported to dramatically reduce disabling pains. Lithium orotate seems to greatly reduce the pain and itching of post-herpetic neuralgia which can linger for months and years after the lesions of shingles have resolved.”
- In 1973, Dr. Hans Nieper reported that approximately 90% of his migraine patients reported significant relief in the frequency and severity of their headaches. He states that he was able to produce these results by utilizing a unique mineral transporter known as orotic acid (aka, orotate), thus allowing him to administer only minute amounts of lithium to achieve maximum results.
- “Lithium orotate contains unparalleled efficiency in the treatment of constitutional migraine, constant headache, and hemicranias, as well as in the treatment of depression, alcoholism and epilepsy… Lithium orotate is effective at uncommonly low serving sizes and causes no negative side effects.” -Dr. Hans Nieper
- Studies of lithium’s effect upon hyperthyroid conditions consistently demonstrate major regulation of thyroid hormones triiodothyronine (T3) and thyroxine (T4). The most common cause of hyperthyroid hormones is Grave’s disease. In a study of lithium’s effect upon Grave’s disease, it was determined that lithium reduced T3 by 42% and T4 by 28%. These amazing changes occurred in just 7 days.
- “Lithium has been reported to be beneficial in animal models of brain injury, stroke, Alzheimer’s, Huntington’s, and Parkinson’s diseases, Amyotrophic Lateral Sclerosis (ALS), spinal cord injury, and other conditions. A recent clinical trial suggests that lithium stops the progression of ALS. The stimulation of endogenous neural stem cells may explain why lithium increases brain cell density and volume in patients with bipolar disorders.”
- The majority of OCD patients are significantly helped by serotonin re-uptake inhibitors (SRIs). “In open-label reports, the addition of… lithium… has yielded encouraging results.”