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Gluten Brain
Wheat Cuts Off Blood Flow To Frontal Cortex
https://www.sott.net/article/288832-Gluten-brain-Wheat-cuts-off-blood-flow-to-frontal-cortex
Sayer Ji
Wake Up World
As far back as 1954, reports of the full or partial resolution of schizophrenia following a gluten free diet began to surface in the medical literature. We covered this remarkable pattern of associations in a previous article titled, "60 Years of Research Links Gluten Grains to Schizophrenia."
While the explanation for this intriguing connection has remained focused on the disruption of the gut-brain axis and the presence in wheat of a wide range of pharmacologically active and mostly opioid receptor modulating polypeptides, a new and possibly more disturbing explanation is beginning to surface: wheat consumption cuts off blood flow to the brain.
Starting with a 1997 case study published in the Journal of Internal Medicine involving a 33-year-old patient, with pre-existing diagnosis of 'schizophrenic' disorder, who first came to medical attention for severe diarrhea and weight loss (classical symptoms of gluten intolerance), brain scan technology determined that cerebral hypoperfusion (decreased blood flow to the brain) was occurring within the patient's frontal cortex.[i] A gluten free diet resulted not only in the normalization of intestinal damage and autoantibodies, but the return of blood flow to the frontal cortex, and the resolution of schizophrenic symptoms.
Then, in 2004, a follow up study was performed to verify if the 1997 case study was just a fluke, or perhaps a widespread effect of untreated celiac disease. Published in the American Journal of Medicine, researchers from the Institute of Internal Medicine, Catholic University, Rome, Italy, compared 15 untreated celiac patients without neurological or psychiatric disorders other than anxiety or depression, with 15 celiac patients who were on a gluten-free diet for almost 1 year, and 24 healthy volunteers of similar sex and age. All subjects underwent cerebral single photon emission computed tomography examination.
The results were remarkable, with dramatically increased incidence of impaired brain blood flow in untreated celiac patients, reported as follows:
"Of the 15 untreated celiac patients, 11 (73%) had at least one hypoperfused brain region, compared with only 1 (7%) of the 15 celiac patients on a gluten-free diet and none of the controls (P = 0.01). Cerebral perfusion was significantly lower (P <0.05) in untreated celiac patients, compared with healthy controls, in 7 of 26 brain regions. No significant differences in cerebral perfusion were found between celiac patients on a gluten-free diet and healthy controls."
They concluded: "There is evidence of regional cerebral blood flow alteration in untreated celiac patients."
Discussion
So, let's take a closer look at what cerebral (brain) hypoperfusion means.
Hypoperfusion is simply decreased blood flow through an organ. Whether it is an internal organ like the kidney, a muscle or the brain, the organ will experience lower availability of oxygen (hypoxia) and nutrients, and will therefore function at a suboptimal level. Cerebral hypoperfusion, therefore, is decreased blood flow to the brain - an organ with extremely high energy demands, and upon which our entire consciousness depends.
Dr. David Perlmutter, author of the #1 New York Times best-selling book Grain Brain, has made great strides in introducing the concept to the world that grains adversely affect brain health. We know that the carbohydrate content of grains alone contribute to disrupting insulin-mediated glucose homeostasis within neurons, ultimately contributing to their suboptimal functioning and in some cases demise, but the discovery that wheat in particular has blood flow disrupting properties to the frontal cortex of the grain, has profound implications.
For example, it is known that the frontal lobe house the 'executive functions' of the brain, including:
If wheat consumption, through some as of yet unknown mechanism, interferes with blood flow to the brain in susceptible individuals, and as a result disrupts the executive functions of the brain, abstaining from it should be considered a reasonable precautionary behavior, assuming we wish to retain these critical functions related to morality, cognizance, and social responsibility.
For additional research on the adverse health effects of wheat, read our article: Wheat: 200 Clinically Confirmed Reasons Not To Eat It.
Also, for more information on the brain-specific harmful effects of wheat, read the following articles or watch the video:
References
[i] A De Santis, G Addolorato, A Romito, S Caputo, A Giordano, G Gambassi, C Taranto, R Manna, G Gasbarrini. Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. J Intern Med. 1997 Nov ;242(5):421-3. PMID: 9408073
Comment:
In view of this research, and with wheat as the staff of life, it's unsurprising if most people can't put two and two together. See also:
Wheat Cuts Off Blood Flow To Frontal Cortex
https://www.sott.net/article/288832-Gluten-brain-Wheat-cuts-off-blood-flow-to-frontal-cortex
Sayer Ji
Wake Up World
As far back as 1954, reports of the full or partial resolution of schizophrenia following a gluten free diet began to surface in the medical literature. We covered this remarkable pattern of associations in a previous article titled, "60 Years of Research Links Gluten Grains to Schizophrenia."
While the explanation for this intriguing connection has remained focused on the disruption of the gut-brain axis and the presence in wheat of a wide range of pharmacologically active and mostly opioid receptor modulating polypeptides, a new and possibly more disturbing explanation is beginning to surface: wheat consumption cuts off blood flow to the brain.
Starting with a 1997 case study published in the Journal of Internal Medicine involving a 33-year-old patient, with pre-existing diagnosis of 'schizophrenic' disorder, who first came to medical attention for severe diarrhea and weight loss (classical symptoms of gluten intolerance), brain scan technology determined that cerebral hypoperfusion (decreased blood flow to the brain) was occurring within the patient's frontal cortex.[i] A gluten free diet resulted not only in the normalization of intestinal damage and autoantibodies, but the return of blood flow to the frontal cortex, and the resolution of schizophrenic symptoms.
Then, in 2004, a follow up study was performed to verify if the 1997 case study was just a fluke, or perhaps a widespread effect of untreated celiac disease. Published in the American Journal of Medicine, researchers from the Institute of Internal Medicine, Catholic University, Rome, Italy, compared 15 untreated celiac patients without neurological or psychiatric disorders other than anxiety or depression, with 15 celiac patients who were on a gluten-free diet for almost 1 year, and 24 healthy volunteers of similar sex and age. All subjects underwent cerebral single photon emission computed tomography examination.
The results were remarkable, with dramatically increased incidence of impaired brain blood flow in untreated celiac patients, reported as follows:
"Of the 15 untreated celiac patients, 11 (73%) had at least one hypoperfused brain region, compared with only 1 (7%) of the 15 celiac patients on a gluten-free diet and none of the controls (P = 0.01). Cerebral perfusion was significantly lower (P <0.05) in untreated celiac patients, compared with healthy controls, in 7 of 26 brain regions. No significant differences in cerebral perfusion were found between celiac patients on a gluten-free diet and healthy controls."
They concluded: "There is evidence of regional cerebral blood flow alteration in untreated celiac patients."
Discussion
So, let's take a closer look at what cerebral (brain) hypoperfusion means.
Hypoperfusion is simply decreased blood flow through an organ. Whether it is an internal organ like the kidney, a muscle or the brain, the organ will experience lower availability of oxygen (hypoxia) and nutrients, and will therefore function at a suboptimal level. Cerebral hypoperfusion, therefore, is decreased blood flow to the brain - an organ with extremely high energy demands, and upon which our entire consciousness depends.
Dr. David Perlmutter, author of the #1 New York Times best-selling book Grain Brain, has made great strides in introducing the concept to the world that grains adversely affect brain health. We know that the carbohydrate content of grains alone contribute to disrupting insulin-mediated glucose homeostasis within neurons, ultimately contributing to their suboptimal functioning and in some cases demise, but the discovery that wheat in particular has blood flow disrupting properties to the frontal cortex of the grain, has profound implications.
For example, it is known that the frontal lobe house the 'executive functions' of the brain, including:
- Recognizing future consequences resulting from current actions
- Choosing between 'good' and 'bad' actions
- Overriding and suppressing socially unacceptable responses
- Retaining longer term memories which are not task-based.
- Determine similarities and differences between things or events.
If wheat consumption, through some as of yet unknown mechanism, interferes with blood flow to the brain in susceptible individuals, and as a result disrupts the executive functions of the brain, abstaining from it should be considered a reasonable precautionary behavior, assuming we wish to retain these critical functions related to morality, cognizance, and social responsibility.
For additional research on the adverse health effects of wheat, read our article: Wheat: 200 Clinically Confirmed Reasons Not To Eat It.
Also, for more information on the brain-specific harmful effects of wheat, read the following articles or watch the video:
- The Grain That Damages The Human Brain, by Sayer Ji
- This Is Your Body (and Brain) on Gluten, by Dr. Kelly Brogan, MD
- Video: Gluten Brain: How Wheat Cuts off Blood Flow - GreenMedTV
References
[i] A De Santis, G Addolorato, A Romito, S Caputo, A Giordano, G Gambassi, C Taranto, R Manna, G Gasbarrini. Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. J Intern Med. 1997 Nov ;242(5):421-3. PMID: 9408073
Comment:
In view of this research, and with wheat as the staff of life, it's unsurprising if most people can't put two and two together. See also:
‘Gluten Brain’
http://healthblog.ivlproducts.com/blog/health-well-being-and-spirituality/gluten-brain-wheat-cuts-off-blood-flow-to-frontal-cortex
by Institute for Vibrant Living
If you suffer from celiac disease or know someone who does, here’s sobering food for thought.
According to health experts, consumption of gluten-containing grains may actually contribute to the development of psychiatric disorders such as schizophrenia; and now new and disturbing research seems to confirm their opinion, by showing that wheat consumption cuts off blood flow to a vital area of the brain.
Celiac disease occurs when your immune system reacts to dietary gluten and manifests as inflammation or irritation of the small intestine, causing problems with absorbing vitamins and minerals from the diet. However, when gluten is removed from the diet, inflammation is reduced or goes away completely and your small intestine begins to heal again.
Let’s look at a 1997 case study published in The Journal of Internal Medicine involving a 33-year-old patient with a pre-existing diagnosis of 'schizophrenic' disorder. This patient first came for medical attention for severe diarrhea and weight loss, both of which are classical symptoms of gluten intolerance.
Brain scans showed that blood flow to the patient's frontal cortex was reduced. In this case, a gluten-free diet not only normalized intestinal damage and auto-antibodies, but raised blood flow again to the frontal cortex, and schizophrenic symptoms disappeared.
A follow-up study was performed in 2004. A total of 15 untreated celiac patients without neurological or psychiatric disorders (other than anxiety or depression) were compared with 15 celiac patients who were on a gluten-free diet for almost one year. Also, 24 healthy volunteers of similar sex and age were included in this study. All subjects underwent a type of brain scan known as cerebral single photon emission computed tomography examination.
The results were truly remarkable.
Of the 15 untreated celiac patients, 11 (73%) had at least one brain region with dramatically lowered blood flow, compared with only 1 (7%) of the 15 celiac patients on a gluten-free diet and none of the controls.
Not only that, blood flow in the frontal cortex was significantly lower in untreated celiac patients compared with healthy controls in 7 of 26 brain regions. Finally, no significant differences in blood flow were found between celiac patients on a gluten-free diet and healthy controls.
The frontal cortex of the brain is responsible for managing 'executive functions', such as:
If wheat consumption interferes so strongly with blood flow to this critical area of the brain, it is likely to disrupt one or more of these executive functions.
So if you are intolerant to gluten in any way, avoiding wheat and gluten altogether may help to protect the health of your brain and perhaps even lower your future risk for schizophrenia.
Read more:
What are the Symptoms of Being Gluten Sensitive?
What are the signs of Small Intestinal Bacterial Overgrowth?
Why Chronic Inflammation is a Risk for Developing Diseases as You Age
Alzheimer's Disease: Early Signs And Risk Factors
Source:
‘Gluten Brain’: Wheat Cuts Off Blood Flow to Frontal Cortex.
You Might Also Like:
How to Live with a Gluten Free Diet and Still Love what You Eat
Quinoa Does Not Worsen Digestive Disorder Associated With Celiac Disease
Over 40 and Can't Lose Weight? Cut Out These Two Foods!
Schizophrenics Have Higher Than Normal Antibodies Against Gluten
http://healthblog.ivlproducts.com/blog/health-well-being-and-spirituality/gluten-brain-wheat-cuts-off-blood-flow-to-frontal-cortex
by Institute for Vibrant Living
If you suffer from celiac disease or know someone who does, here’s sobering food for thought.
According to health experts, consumption of gluten-containing grains may actually contribute to the development of psychiatric disorders such as schizophrenia; and now new and disturbing research seems to confirm their opinion, by showing that wheat consumption cuts off blood flow to a vital area of the brain.
Celiac disease occurs when your immune system reacts to dietary gluten and manifests as inflammation or irritation of the small intestine, causing problems with absorbing vitamins and minerals from the diet. However, when gluten is removed from the diet, inflammation is reduced or goes away completely and your small intestine begins to heal again.
Let’s look at a 1997 case study published in The Journal of Internal Medicine involving a 33-year-old patient with a pre-existing diagnosis of 'schizophrenic' disorder. This patient first came for medical attention for severe diarrhea and weight loss, both of which are classical symptoms of gluten intolerance.
Brain scans showed that blood flow to the patient's frontal cortex was reduced. In this case, a gluten-free diet not only normalized intestinal damage and auto-antibodies, but raised blood flow again to the frontal cortex, and schizophrenic symptoms disappeared.
A follow-up study was performed in 2004. A total of 15 untreated celiac patients without neurological or psychiatric disorders (other than anxiety or depression) were compared with 15 celiac patients who were on a gluten-free diet for almost one year. Also, 24 healthy volunteers of similar sex and age were included in this study. All subjects underwent a type of brain scan known as cerebral single photon emission computed tomography examination.
The results were truly remarkable.
Of the 15 untreated celiac patients, 11 (73%) had at least one brain region with dramatically lowered blood flow, compared with only 1 (7%) of the 15 celiac patients on a gluten-free diet and none of the controls.
Not only that, blood flow in the frontal cortex was significantly lower in untreated celiac patients compared with healthy controls in 7 of 26 brain regions. Finally, no significant differences in blood flow were found between celiac patients on a gluten-free diet and healthy controls.
The frontal cortex of the brain is responsible for managing 'executive functions', such as:
- Recognizing future consequences as a result of current actions;
- Choosing between 'good' and 'bad' actions;
- Overriding and suppressing socially unacceptable responses;
- Retaining longer term memories which are not task-based;
- Being able to determine similarities and differences between things or events.
If wheat consumption interferes so strongly with blood flow to this critical area of the brain, it is likely to disrupt one or more of these executive functions.
So if you are intolerant to gluten in any way, avoiding wheat and gluten altogether may help to protect the health of your brain and perhaps even lower your future risk for schizophrenia.
Read more:
What are the Symptoms of Being Gluten Sensitive?
What are the signs of Small Intestinal Bacterial Overgrowth?
Why Chronic Inflammation is a Risk for Developing Diseases as You Age
Alzheimer's Disease: Early Signs And Risk Factors
Source:
‘Gluten Brain’: Wheat Cuts Off Blood Flow to Frontal Cortex.
You Might Also Like:
How to Live with a Gluten Free Diet and Still Love what You Eat
Quinoa Does Not Worsen Digestive Disorder Associated With Celiac Disease
Over 40 and Can't Lose Weight? Cut Out These Two Foods!
Schizophrenics Have Higher Than Normal Antibodies Against Gluten
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